Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial
Abstract Background Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between cha...
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doaj-a761bdd50d7747d9afabe350237352962020-11-25T00:36:29ZengBMCBMC Psychiatry1471-244X2018-03-011811810.1186/s12888-018-1667-1Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trialTsubasa Morimoto0Yasuhiro Matsuda1Kiwamu Matsuoka2Fumihiko Yasuno3Emi Ikebuchi4Hiroyuki Kameda5Toshiaki Taoka6Toshiteru Miyasaka7Kimihiko Kichikawa8Toshifumi Kishimoto9Department of Psychiatry, Nara Medical University School of MedicineDepartment of Psychiatry, Nara Medical University School of MedicineDepartment of Psychiatry, Nara Medical University School of MedicineDepartment of Psychiatry, Nara Medical University School of MedicineDepartment of Psychiatry, Teikyo University School of MedicineSchool of Computer Science, Tokyo University of TechnologyDepartment of Radiology, Nagoya University HospitalDepartment of Radiology, Nara Medical University School of MedicineDepartment of Radiology, Nara Medical University School of MedicineDepartment of Psychiatry, Nara Medical University School of MedicineAbstract Background Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between changes in cortical volume and neurocognitive performance. Method Between August 2013 and September 2016, we performed a randomized controlled study comprising a CRT group (16 individuals) and a treatment-as-usual (TAU) group (15 individuals) of patients with schizophrenia. CRT participants engaged in twice-weekly computer-assisted CRT sessions and weekly group meetings for 12 weeks. T1-weighted magnetic resonance imaging was performed before and after the intervention period, and whole-brain voxel-based morphometric analysis was used to detect significant cortical gray matter volume changes. We also assessed the correlation between cortical volume changes and CRT-derived neurocognitive improvements. Results The CRT group exhibited significantly greater improvements than the TAU group in verbal fluency (P = 0.012) and global cognitive scores (P = 0.049). The CRT group also exhibited significantly greater increases in right hippocampal volume than the TAU group (P < 0.001). Changes in verbal fluency scores and right hippocampal volumes were positively correlated (r = 0.53, P = 0.001). Conclusion We found that CRT significantly increased right hippocampal volumes and that these enhancements were positively correlated with changes in verbal fluency scores. Our results indicate that CRT induces cognitive improvement through hippocampal plasticity. Trial registration Registration number: UMIN000026146, 2017/02/15, retrospectively registered.http://link.springer.com/article/10.1186/s12888-018-1667-1Cognitive remediationRehabilitationStructural neuroimagingHippocampusSchizophreniaJcores |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tsubasa Morimoto Yasuhiro Matsuda Kiwamu Matsuoka Fumihiko Yasuno Emi Ikebuchi Hiroyuki Kameda Toshiaki Taoka Toshiteru Miyasaka Kimihiko Kichikawa Toshifumi Kishimoto |
spellingShingle |
Tsubasa Morimoto Yasuhiro Matsuda Kiwamu Matsuoka Fumihiko Yasuno Emi Ikebuchi Hiroyuki Kameda Toshiaki Taoka Toshiteru Miyasaka Kimihiko Kichikawa Toshifumi Kishimoto Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial BMC Psychiatry Cognitive remediation Rehabilitation Structural neuroimaging Hippocampus Schizophrenia Jcores |
author_facet |
Tsubasa Morimoto Yasuhiro Matsuda Kiwamu Matsuoka Fumihiko Yasuno Emi Ikebuchi Hiroyuki Kameda Toshiaki Taoka Toshiteru Miyasaka Kimihiko Kichikawa Toshifumi Kishimoto |
author_sort |
Tsubasa Morimoto |
title |
Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
title_short |
Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
title_full |
Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
title_fullStr |
Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
title_full_unstemmed |
Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
title_sort |
computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial |
publisher |
BMC |
series |
BMC Psychiatry |
issn |
1471-244X |
publishDate |
2018-03-01 |
description |
Abstract Background Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between changes in cortical volume and neurocognitive performance. Method Between August 2013 and September 2016, we performed a randomized controlled study comprising a CRT group (16 individuals) and a treatment-as-usual (TAU) group (15 individuals) of patients with schizophrenia. CRT participants engaged in twice-weekly computer-assisted CRT sessions and weekly group meetings for 12 weeks. T1-weighted magnetic resonance imaging was performed before and after the intervention period, and whole-brain voxel-based morphometric analysis was used to detect significant cortical gray matter volume changes. We also assessed the correlation between cortical volume changes and CRT-derived neurocognitive improvements. Results The CRT group exhibited significantly greater improvements than the TAU group in verbal fluency (P = 0.012) and global cognitive scores (P = 0.049). The CRT group also exhibited significantly greater increases in right hippocampal volume than the TAU group (P < 0.001). Changes in verbal fluency scores and right hippocampal volumes were positively correlated (r = 0.53, P = 0.001). Conclusion We found that CRT significantly increased right hippocampal volumes and that these enhancements were positively correlated with changes in verbal fluency scores. Our results indicate that CRT induces cognitive improvement through hippocampal plasticity. Trial registration Registration number: UMIN000026146, 2017/02/15, retrospectively registered. |
topic |
Cognitive remediation Rehabilitation Structural neuroimaging Hippocampus Schizophrenia Jcores |
url |
http://link.springer.com/article/10.1186/s12888-018-1667-1 |
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