An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases
Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumo...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-11-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332221009914 |
id |
doaj-a761d1b9c72942cb976fbda5d173c508 |
---|---|
record_format |
Article |
spelling |
doaj-a761d1b9c72942cb976fbda5d173c5082021-10-11T04:15:14ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-11-01143112207An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseasesNazhan Ilias0Hazilawati Hamzah1Intan Safinar Ismail2Taznim Begam Mohd. Mohidin3Mohd. Faiz Idris4Mokrish Ajat5Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, MalaysiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Malaysia; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, MalaysiaInstitute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaPusat Bahasa dan Pengajian Umum, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, MalaysiaDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Malaysia; Natural Medicines and Products Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Malaysia; Corresponding author at: Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Malaysia.Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumorigenic, anti-diabetic, and anti-hyperlipidemia. Statins (3-hydro-3-methylglutaryl-coenzyme A reductase inhibitor) are a class of drugs used to treat atherosclerosis. Statins are explicitly targeting the HMG-CoA reductase, an enzyme in the rate-limiting step of cholesterol biosynthesis. Despite being widely used in regulating plasma cholesterol levels, the adverse effects of the drug are a significant concern among clinicians and patients. Hence, steviol glycosides derived from stevia have been proposed as an alternative in replacing statins. Diterpene glycosides from stevia, such as stevioside and rebaudioside A have been evaluated for their efficacy in alleviating cholesterol levels. These glycosides are a potential candidate in treating and preventing atherosclerosis provoked by circulating lipid retention in the sub-endothelial lining of the artery. The present review is an effort to integrate the pathogenesis of atherosclerosis, involvement of lipid droplets biogenesis and its associated proteins in atherogenesis, current approaches to treat atherosclerosis, and pharmacological potential of stevia in treating the disease.http://www.sciencedirect.com/science/article/pii/S0753332221009914AtherosclerosisAnti-hyperlipidemiaLow-density lipoproteinLipid dropletsStatinsStevia rebaudiana Bertoni |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nazhan Ilias Hazilawati Hamzah Intan Safinar Ismail Taznim Begam Mohd. Mohidin Mohd. Faiz Idris Mokrish Ajat |
spellingShingle |
Nazhan Ilias Hazilawati Hamzah Intan Safinar Ismail Taznim Begam Mohd. Mohidin Mohd. Faiz Idris Mokrish Ajat An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases Biomedicine & Pharmacotherapy Atherosclerosis Anti-hyperlipidemia Low-density lipoprotein Lipid droplets Statins Stevia rebaudiana Bertoni |
author_facet |
Nazhan Ilias Hazilawati Hamzah Intan Safinar Ismail Taznim Begam Mohd. Mohidin Mohd. Faiz Idris Mokrish Ajat |
author_sort |
Nazhan Ilias |
title |
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
title_short |
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
title_full |
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
title_fullStr |
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
title_full_unstemmed |
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
title_sort |
insight on the future therapeutic application potential of stevia rebaudiana bertoni for atherosclerosis and cardiovascular diseases |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-11-01 |
description |
Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumorigenic, anti-diabetic, and anti-hyperlipidemia. Statins (3-hydro-3-methylglutaryl-coenzyme A reductase inhibitor) are a class of drugs used to treat atherosclerosis. Statins are explicitly targeting the HMG-CoA reductase, an enzyme in the rate-limiting step of cholesterol biosynthesis. Despite being widely used in regulating plasma cholesterol levels, the adverse effects of the drug are a significant concern among clinicians and patients. Hence, steviol glycosides derived from stevia have been proposed as an alternative in replacing statins. Diterpene glycosides from stevia, such as stevioside and rebaudioside A have been evaluated for their efficacy in alleviating cholesterol levels. These glycosides are a potential candidate in treating and preventing atherosclerosis provoked by circulating lipid retention in the sub-endothelial lining of the artery. The present review is an effort to integrate the pathogenesis of atherosclerosis, involvement of lipid droplets biogenesis and its associated proteins in atherogenesis, current approaches to treat atherosclerosis, and pharmacological potential of stevia in treating the disease. |
topic |
Atherosclerosis Anti-hyperlipidemia Low-density lipoprotein Lipid droplets Statins Stevia rebaudiana Bertoni |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221009914 |
work_keys_str_mv |
AT nazhanilias aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT hazilawatihamzah aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT intansafinarismail aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT taznimbegammohdmohidin aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT mohdfaizidris aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT mokrishajat aninsightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT nazhanilias insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT hazilawatihamzah insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT intansafinarismail insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT taznimbegammohdmohidin insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT mohdfaizidris insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases AT mokrishajat insightonthefuturetherapeuticapplicationpotentialofsteviarebaudianabertoniforatherosclerosisandcardiovasculardiseases |
_version_ |
1716828826056523776 |