Hesperidin: A Therapeutic Agent For Obesity

• Main Authors: Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, Hu J, Sun J, Yao R, Huang Q
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-11-01
• Series: Drug Design, Development and Therapy
• Subjects: citrus flavonoids; lipid metabolism; glucose metabolism; anti-oxidation; anti-inflammatory
• Online Access: https://www.dovepress.com/hesperidin-a-therapeutic-agent-for-obesity-peer-reviewed-article-DDDT
• ISSN: 1177-8881

Haijun Xiong,1 Jin Wang,1 Qian Ran,1 Guanhua Lou,1 Chengyi Peng,1 Qingxia Gan,1 Ju Hu,1 Jilin Sun,2 Renchuan Yao,3 Qinwan Huang1,4 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China; 2Sichuan Fuzheng Pharmaceutical Co. Ltd, Sichuan, People’s Republic of China; 3Sichuan Fermentation Traditional Chinese Medicine Engineering Research Center, Chengdu, People’s Republic of China; 4State Key Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of ChinaCorrespondence: Qinwan HuangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu 611137, People’s Republic of ChinaTel [phone]Fax [phone]Email [e-mail]: Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.Keywords: citrus flavonoids, lipid metabolism, glucose metabolism, anti-oxidation, anti-inflammatory