Correlation of renal volume to renal function and blood pressures in low birth weight children

Background Disruption of nephrogenesis in low birth weight (LBW) infant leads to decreases in nephron number and renal volume, resulting in renal hyperfunction and eventually, hypertension. Objective To assess for a possible correlation of renal volume to renal function and blood pressures in low bi...

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Main Authors: Ekawaty Larope, Adrian Umboh, Rocky Wilar
Format: Article
Language:English
Published: Indonesian Pediatric Society Publishing House 2014-04-01
Series:Paediatrica Indonesiana
Subjects:
Online Access:https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/210
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spelling doaj-a76810095a3544169782f842cb8ddd352020-11-25T00:52:37ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2014-04-0154273610.14238/pi54.2.2014.73-6127Correlation of renal volume to renal function and blood pressures in low birth weight childrenEkawaty Larope0Adrian Umboh1Rocky Wilar2Department of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou HospitalDepartment of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou HospitalDepartment of Child Health, Sam Ratulangi University Medical School/Prof. Dr. R. D. Kandou HospitalBackground Disruption of nephrogenesis in low birth weight (LBW) infant leads to decreases in nephron number and renal volume, resulting in renal hyperfunction and eventually, hypertension. Objective To assess for a possible correlation of renal volume to renal function and blood pressures in low birth weight children aged 7 -8 years. Methods We conducted a retrospective cohort study on children aged 7-8 years in Manado, who were born LBW or n ormal birth weight (NBW). Renal function was assessed by measuring blood cyctatin-C level while renal volume was determined using ultrasound measurements of renal length x width x thickness (cm3). Ttest was used to compare renal volume and cystatin-C levels in LBW children to NBW children. Pearson's correlation test was used to assess the relationship of renal volume to renal function and blood pressure in low birth weight children. Results Subjects were 48 LBW and 48 NBW children. Mean renal volumes were 7 8.28 (SD 7 .96) cm3 in the LBW group and 103.68 (SD 12.52) cm3 in the NBW group (P< 0.01). The mean cystatin-C levels, as a measure of renal function, were 0.81 (SD 0.07) mg/Lin the LBW group and in 0.73 (SD 0.06) mg/Lin the NBW group (P< 0.01). There was no correlation between renal volume and cystatin-C level (r=-0.169; P>0,05) as well as between renal volume and systolic (r=-0.07, P>0.05) and dias tolic blood pressure (r=-0.123, P>0.05). Conclusion Mean renal volume is lower in the LBW group than in the NBW group, but is not correlated to decreased renal function or blood pressures.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/210renal volume, renal function, low birth weight, blood pressure
collection DOAJ
language English
format Article
sources DOAJ
author Ekawaty Larope
Adrian Umboh
Rocky Wilar
spellingShingle Ekawaty Larope
Adrian Umboh
Rocky Wilar
Correlation of renal volume to renal function and blood pressures in low birth weight children
Paediatrica Indonesiana
renal volume, renal function, low birth weight, blood pressure
author_facet Ekawaty Larope
Adrian Umboh
Rocky Wilar
author_sort Ekawaty Larope
title Correlation of renal volume to renal function and blood pressures in low birth weight children
title_short Correlation of renal volume to renal function and blood pressures in low birth weight children
title_full Correlation of renal volume to renal function and blood pressures in low birth weight children
title_fullStr Correlation of renal volume to renal function and blood pressures in low birth weight children
title_full_unstemmed Correlation of renal volume to renal function and blood pressures in low birth weight children
title_sort correlation of renal volume to renal function and blood pressures in low birth weight children
publisher Indonesian Pediatric Society Publishing House
series Paediatrica Indonesiana
issn 0030-9311
2338-476X
publishDate 2014-04-01
description Background Disruption of nephrogenesis in low birth weight (LBW) infant leads to decreases in nephron number and renal volume, resulting in renal hyperfunction and eventually, hypertension. Objective To assess for a possible correlation of renal volume to renal function and blood pressures in low birth weight children aged 7 -8 years. Methods We conducted a retrospective cohort study on children aged 7-8 years in Manado, who were born LBW or n ormal birth weight (NBW). Renal function was assessed by measuring blood cyctatin-C level while renal volume was determined using ultrasound measurements of renal length x width x thickness (cm3). Ttest was used to compare renal volume and cystatin-C levels in LBW children to NBW children. Pearson's correlation test was used to assess the relationship of renal volume to renal function and blood pressure in low birth weight children. Results Subjects were 48 LBW and 48 NBW children. Mean renal volumes were 7 8.28 (SD 7 .96) cm3 in the LBW group and 103.68 (SD 12.52) cm3 in the NBW group (P< 0.01). The mean cystatin-C levels, as a measure of renal function, were 0.81 (SD 0.07) mg/Lin the LBW group and in 0.73 (SD 0.06) mg/Lin the NBW group (P< 0.01). There was no correlation between renal volume and cystatin-C level (r=-0.169; P>0,05) as well as between renal volume and systolic (r=-0.07, P>0.05) and dias tolic blood pressure (r=-0.123, P>0.05). Conclusion Mean renal volume is lower in the LBW group than in the NBW group, but is not correlated to decreased renal function or blood pressures.
topic renal volume, renal function, low birth weight, blood pressure
url https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/210
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AT adrianumboh correlationofrenalvolumetorenalfunctionandbloodpressuresinlowbirthweightchildren
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