Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17...

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Main Authors:	Yakubu Saddeeq Abubakar, Wenhui Zheng, Stefan Olsson, Jie Zhou
Format:	Article
Language:	English
Published:	MDPI AG 2017-07-01
Series:	International Journal of Molecular Sciences
Subjects:	retromer receptors vacuolar protein sorting endosome disease
Online Access:	https://www.mdpi.com/1422-0067/18/8/1601

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spelling	doaj-a773e5ad7f5c42fe8b0091a89615517f2020-11-24T21:18:01ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-07-01188160110.3390/ijms18081601ijms18081601Updated Insight into the Physiological and Pathological Roles of the Retromer ComplexYakubu Saddeeq Abubakar0Wenhui Zheng1Stefan Olsson2Jie Zhou3State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaRetromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.https://www.mdpi.com/1422-0067/18/8/1601retromerreceptorsvacuolar protein sortingendosomedisease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yakubu Saddeeq Abubakar Wenhui Zheng Stefan Olsson Jie Zhou
spellingShingle	Yakubu Saddeeq Abubakar Wenhui Zheng Stefan Olsson Jie Zhou Updated Insight into the Physiological and Pathological Roles of the Retromer Complex International Journal of Molecular Sciences retromer receptors vacuolar protein sorting endosome disease
author_facet	Yakubu Saddeeq Abubakar Wenhui Zheng Stefan Olsson Jie Zhou
author_sort	Yakubu Saddeeq Abubakar
title	Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
title_short	Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
title_full	Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
title_fullStr	Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
title_full_unstemmed	Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
title_sort	updated insight into the physiological and pathological roles of the retromer complex
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2017-07-01
description	Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.
topic	retromer receptors vacuolar protein sorting endosome disease
url	https://www.mdpi.com/1422-0067/18/8/1601
work_keys_str_mv	AT yakubusaddeeqabubakar updatedinsightintothephysiologicalandpathologicalrolesoftheretromercomplex AT wenhuizheng updatedinsightintothephysiologicalandpathologicalrolesoftheretromercomplex AT stefanolsson updatedinsightintothephysiologicalandpathologicalrolesoftheretromercomplex AT jiezhou updatedinsightintothephysiologicalandpathologicalrolesoftheretromercomplex
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Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

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