Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis
Background: To determine the respiratory outcomes in patients following COVID-19-related hospitalization.Methods: Systematic review and meta-analysis of the literature.Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharg...
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2021-10-01
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doaj-a77a5df6e29443e89aee29296858259f2021-10-06T07:57:24ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-10-01810.3389/fmolb.2021.750558750558Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-AnalysisTao Guo0Fangfang Jiang1Yufei Liu2Yunpeng Zhao3Yiran Li4Yihua Wang5Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United KingdomDepartment of Mathematical Sciences, Faculty of Social Sciences, University of Southampton, Southampton, United KingdomSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Medicine and Integrated Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, Nanjing, ChinaBiological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United KingdomBackground: To determine the respiratory outcomes in patients following COVID-19-related hospitalization.Methods: Systematic review and meta-analysis of the literature.Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8–118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0–3 months post discharge: 83.9, 95% CI [68.9–98.9]; 3–6 months post discharge: 91.2, 95% CI [74.8–107.7]; >6 months post discharge: 97.3, 95% CI [76.7–117.9]. Percentage of patients with FVC less than 80% of predicted: 0–3 months post discharge: 10%, 95% CI [6–14%]; 3–6 months post discharge: 10%, 95% CI [2–18%]; >6 months post discharge: 13%, 95% CI [8–18%]. Percentage of patients with DLCO less than 80% of predicted: 0–3 months post discharge: 48%, 95% CI [41–56%]; 3–6 months post discharge: 33%, 95% CI [23–44%]; >6 months post discharge: 43%, 95% CI [22–65%].Conclusion: The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended.https://www.frontiersin.org/articles/10.3389/fmolb.2021.750558/fullCOVID-19follow-uppulmonary function testFVCDLCOsynthesis review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tao Guo Fangfang Jiang Yufei Liu Yunpeng Zhao Yiran Li Yihua Wang |
spellingShingle |
Tao Guo Fangfang Jiang Yufei Liu Yunpeng Zhao Yiran Li Yihua Wang Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis Frontiers in Molecular Biosciences COVID-19 follow-up pulmonary function test FVC DLCO synthesis review |
author_facet |
Tao Guo Fangfang Jiang Yufei Liu Yunpeng Zhao Yiran Li Yihua Wang |
author_sort |
Tao Guo |
title |
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis |
title_short |
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis |
title_full |
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis |
title_fullStr |
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis |
title_full_unstemmed |
Respiratory Outcomes in Patients Following COVID-19-Related Hospitalization: A Meta-Analysis |
title_sort |
respiratory outcomes in patients following covid-19-related hospitalization: a meta-analysis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2021-10-01 |
description |
Background: To determine the respiratory outcomes in patients following COVID-19-related hospitalization.Methods: Systematic review and meta-analysis of the literature.Results: Forced vital capacity (FVC, % of predicted): 0–3 months post discharge: 96.1, 95% CI [82.1–110.0]; 3–6 months post discharge: 99.9, 95% CI [84.8, 115.0]; >6 months post discharge: 97.4, 95% CI [76.8–118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0–3 months post discharge: 83.9, 95% CI [68.9–98.9]; 3–6 months post discharge: 91.2, 95% CI [74.8–107.7]; >6 months post discharge: 97.3, 95% CI [76.7–117.9]. Percentage of patients with FVC less than 80% of predicted: 0–3 months post discharge: 10%, 95% CI [6–14%]; 3–6 months post discharge: 10%, 95% CI [2–18%]; >6 months post discharge: 13%, 95% CI [8–18%]. Percentage of patients with DLCO less than 80% of predicted: 0–3 months post discharge: 48%, 95% CI [41–56%]; 3–6 months post discharge: 33%, 95% CI [23–44%]; >6 months post discharge: 43%, 95% CI [22–65%].Conclusion: The meta-analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalization. Routine respiratory follow-up is thus strongly recommended. |
topic |
COVID-19 follow-up pulmonary function test FVC DLCO synthesis review |
url |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.750558/full |
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