Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis Helicobacter pylori rat model

• Main Authors: OK Yulizal, Setia Budi Tarigan, OK Isnainul, Zainul Muttaqin
• Format: Article
• Language: English
• Published: Network for the Veterinarians of Bangladesh 2021-03-01
• Series: Journal of Advanced Veterinary and Animal Research
• Subjects: gastritis; helicobacter pylori; histopathological features; omeprazole; amoxicillin; clarithromycin
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=24536

Objective: This research work aimed to assess the histopathological features and degree of gas¬tritis severity in a rat model, induced by Helicobacter pylori infection after administering omepra¬zole, amoxicillin, and clarithromycin as the standard first-line eradication regimen. Material and Methods: Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control. Group 2 and Group 3 were treated as H. pylori-inoculated groups. Group 2 was set as a positive control. Group 3 was admin¬istered omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen. Gastric histopathological examination was conducted. The difference in the severity of gastritis among the groups was examined using the one-way analysis of variance test. The significance was deter¬mined to be p < 0.05. Results: Gastritis was found in all inoculated groups. The severity of gastritis was highest in Group 2 (p < 0.05). We could see a refinement in gastritis severity after administering omeprazole, amox¬icillin, and clarithromycin as a first-line eradication regimen (Group 3 vs. Group 2; p [J Adv Vet Anim Res 2021; 8(1.000): 158-163]