Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor
Background Tobacco smoking (TS) remains the most established cause of lung carcinogenesis and other disease processes. In Kazakhstan lung cancer (LC) occupies by far the first position in the cancer mortality structure. Identification of the morphological and immunohistochemical features of tumors...
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doaj-a77f90fa59624490a2d911f3f17e8ac82020-11-24T21:58:42ZengEuropean PublishingTobacco Induced Diseases1617-96252018-03-0116110.18332/tid/8460384603Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumorGulsum Smagulova0Alma Zhylkaidarova1Kazakh Institute of Oncology and Radiology, KazakhstanKazakh Institute of Oncology and Radiology, KazakhstanBackground Tobacco smoking (TS) remains the most established cause of lung carcinogenesis and other disease processes. In Kazakhstan lung cancer (LC) occupies by far the first position in the cancer mortality structure. Identification of the morphological and immunohistochemical features of tumors among smokers may enable individualized treatment and reduce mortality. Methods Morphological, histological, molecular genetics, immunohistochemical methods were used. The slides of 286 patients (204 smokers and 82 nonsmokers) with LC were studied. For molecular genetic studies tumor blocks of 47 patients (27 smokers and 20 nonsmokers) were used. Results There are differences in the histotype structure of LC among smokers and nonsmokers. Squamous cell carcinoma prevails among men as adenocarcinoma among women. It was found that smokers had squamous cell carcinoma histotype predominant, which share above 1.4 times (p < 0.01), and small cell carcinoma 2.0 times (p < 0.05). Adenocarcinoma is 3.5 times (p < 0.001) more likely to develop in the group of non-smokers. Activating of epidermal growth factor receptor mutations were detected in 21.3% of the patients with non-small cell LC. Mutations occur most often among women (70%) than among men (30%) and most among non-smokers than among smokers (90% and 10% respectively). Immunohistochemical studies of LC tumor have shown that smokers have a higher proliferative activity of tumor cells, indicating the adverse effects of smoking for the LC prognosis. Conclusions The data obtained allow to individualize the postoperative radiation therapy and adjuvant chemotherapy to improve the efficiency of LC treatment. Considering that the presence of the mutations associated with the possibility of targeted therapy, LC treatment prognosis in smokers less favorable than that of nonsmokers. Advising the patient to quit by clinicians is an important preventive technology for prevention of LC morbidity and premature mortality.http://www.journalssystem.com/tid/Estimation-of-the-impact-of-tobacco-smoking-factor-on-the-morphological-molecular,84603,0,2.htmlWCTOH |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gulsum Smagulova Alma Zhylkaidarova |
spellingShingle |
Gulsum Smagulova Alma Zhylkaidarova Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor Tobacco Induced Diseases WCTOH |
author_facet |
Gulsum Smagulova Alma Zhylkaidarova |
author_sort |
Gulsum Smagulova |
title |
Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
title_short |
Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
title_full |
Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
title_fullStr |
Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
title_full_unstemmed |
Estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
title_sort |
estimation of the impact of tobacco smoking factor on the morphological, molecular and genetic parameters of the lung cancer tumor |
publisher |
European Publishing |
series |
Tobacco Induced Diseases |
issn |
1617-9625 |
publishDate |
2018-03-01 |
description |
Background
Tobacco smoking (TS) remains the most established cause of lung carcinogenesis
and other disease processes. In Kazakhstan lung cancer (LC) occupies by far the first position in the cancer mortality
structure. Identification of the morphological and immunohistochemical features of tumors among smokers
may enable individualized treatment and reduce mortality.
Methods
Morphological, histological, molecular genetics, immunohistochemical
methods were used. The slides of 286 patients (204 smokers and 82 nonsmokers) with
LC were studied. For molecular genetic studies tumor blocks of 47 patients (27
smokers and 20 nonsmokers) were used.
Results
There are differences in the histotype structure of LC among smokers and
nonsmokers. Squamous cell carcinoma prevails among men as adenocarcinoma among
women. It was found that smokers had squamous cell carcinoma histotype
predominant, which share above 1.4 times (p < 0.01), and small cell
carcinoma 2.0 times (p < 0.05). Adenocarcinoma is 3.5 times (p < 0.001)
more likely to develop in the group of non-smokers. Activating of epidermal
growth factor receptor mutations were detected in 21.3% of the patients with
non-small cell LC. Mutations occur most often among women (70%) than among men
(30%) and most among non-smokers than among smokers (90% and 10% respectively).
Immunohistochemical studies of LC tumor have shown that smokers have a higher
proliferative activity of tumor cells, indicating the adverse effects of
smoking for the LC prognosis.
Conclusions
The data obtained allow to individualize the postoperative radiation therapy and adjuvant chemotherapy to improve the efficiency of LC treatment. Considering that the presence of the mutations associated with the possibility of targeted therapy, LC treatment prognosis in smokers less favorable than that of nonsmokers. Advising the patient to quit by clinicians is an important preventive technology for prevention of LC morbidity and premature mortality. |
topic |
WCTOH |
url |
http://www.journalssystem.com/tid/Estimation-of-the-impact-of-tobacco-smoking-factor-on-the-morphological-molecular,84603,0,2.html |
work_keys_str_mv |
AT gulsumsmagulova estimationoftheimpactoftobaccosmokingfactoronthemorphologicalmolecularandgeneticparametersofthelungcancertumor AT almazhylkaidarova estimationoftheimpactoftobaccosmokingfactoronthemorphologicalmolecularandgeneticparametersofthelungcancertumor |
_version_ |
1725850628656201728 |