Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels
Fructosamine is an alternative method to hemoglobin A1c (HbA1c) for determining average glycemia. However, its use has not been extensively evaluated in persons living with HIV (PLWH). We examined the relationship between HbA1c and fructosamine values, specifically focusing on anemia (which can affe...
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doaj-a785aa3440994fd8923348bdf0fe75882020-11-25T00:06:42ZengHindawi LimitedAIDS Research and Treatment2090-12402090-12592015-01-01201510.1155/2015/478750478750Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin LevelsLuisa Duran0Carla Rodriguez1Dan Drozd2Robin M. Nance3J. A. Chris Delaney4Greer Burkholder5Michael J. Mugavero6James H. Willig7Amy H. Warriner8Paul K. Crane9Ben E. Atkinson10Robert D. Harrington11Shireesha Dhanireddy12Michael S. Saag13Mari M. Kitahata14Heidi M. Crane15University of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Alabama at Birmingham, Birmingham, AL 35294, USAUniversity of Alabama at Birmingham, Birmingham, AL 35294, USAUniversity of Alabama at Birmingham, Birmingham, AL 35294, USAUniversity of Alabama at Birmingham, Birmingham, AL 35294, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Alabama at Birmingham, Birmingham, AL 35294, USAUniversity of Washington, Seattle, WA 98195, USAUniversity of Washington, Seattle, WA 98195, USAFructosamine is an alternative method to hemoglobin A1c (HbA1c) for determining average glycemia. However, its use has not been extensively evaluated in persons living with HIV (PLWH). We examined the relationship between HbA1c and fructosamine values, specifically focusing on anemia (which can affect HbA1c) and albumin as a marker of liver disease. We included 345 PLWH from two sites. We examined Spearman rank correlations between fructosamine and HbA1c and performed linear test for trends to compare fructosamine and HbA1c correlations by hemoglobin and albumin quartiles. We examined discrepant individuals with values elevated only on one test. We found a correlation of 0.70 between fructosamine and HbA1c levels. Trend tests for correlations between fructosamine and HbA1c were significant for both albumin (p=0.05) and hemoglobin (p=0.01) with the lowest correlations in the lowest hemoglobin quartile. We identified participants with unremarkable HbA1c values but elevated fructosamine values. These discrepant individuals had lower mean hemoglobin levels than those elevated by both tests. We demonstrated a large correlation between HbA1c and fructosamine across a range of hemoglobin and albumin levels. There were discrepant cases particularly among those with lower hemoglobin levels. Future studies are needed to clarify the use of fructosamine for diabetes management in PWLH.http://dx.doi.org/10.1155/2015/478750 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luisa Duran Carla Rodriguez Dan Drozd Robin M. Nance J. A. Chris Delaney Greer Burkholder Michael J. Mugavero James H. Willig Amy H. Warriner Paul K. Crane Ben E. Atkinson Robert D. Harrington Shireesha Dhanireddy Michael S. Saag Mari M. Kitahata Heidi M. Crane |
spellingShingle |
Luisa Duran Carla Rodriguez Dan Drozd Robin M. Nance J. A. Chris Delaney Greer Burkholder Michael J. Mugavero James H. Willig Amy H. Warriner Paul K. Crane Ben E. Atkinson Robert D. Harrington Shireesha Dhanireddy Michael S. Saag Mari M. Kitahata Heidi M. Crane Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels AIDS Research and Treatment |
author_facet |
Luisa Duran Carla Rodriguez Dan Drozd Robin M. Nance J. A. Chris Delaney Greer Burkholder Michael J. Mugavero James H. Willig Amy H. Warriner Paul K. Crane Ben E. Atkinson Robert D. Harrington Shireesha Dhanireddy Michael S. Saag Mari M. Kitahata Heidi M. Crane |
author_sort |
Luisa Duran |
title |
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels |
title_short |
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels |
title_full |
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels |
title_fullStr |
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels |
title_full_unstemmed |
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels |
title_sort |
fructosamine and hemoglobin a1c correlations in hiv-infected adults in routine clinical care: impact of anemia and albumin levels |
publisher |
Hindawi Limited |
series |
AIDS Research and Treatment |
issn |
2090-1240 2090-1259 |
publishDate |
2015-01-01 |
description |
Fructosamine is an alternative method to hemoglobin A1c (HbA1c) for determining average glycemia. However, its use has not been extensively evaluated in persons living with HIV (PLWH). We examined the relationship between HbA1c and fructosamine values, specifically focusing on anemia (which can affect HbA1c) and albumin as a marker of liver disease. We included 345 PLWH from two sites. We examined Spearman rank correlations between fructosamine and HbA1c and performed linear test for trends to compare fructosamine and HbA1c correlations by hemoglobin and albumin quartiles. We examined discrepant individuals with values elevated only on one test. We found a correlation of 0.70 between fructosamine and HbA1c levels. Trend tests for correlations between fructosamine and HbA1c were significant for both albumin (p=0.05) and hemoglobin (p=0.01) with the lowest correlations in the lowest hemoglobin quartile. We identified participants with unremarkable HbA1c values but elevated fructosamine values. These discrepant individuals had lower mean hemoglobin levels than those elevated by both tests. We demonstrated a large correlation between HbA1c and fructosamine across a range of hemoglobin and albumin levels. There were discrepant cases particularly among those with lower hemoglobin levels. Future studies are needed to clarify the use of fructosamine for diabetes management in PWLH. |
url |
http://dx.doi.org/10.1155/2015/478750 |
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