High mortality due to accidental salinomycin intoxication in sheep
In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Labor...
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doaj-a786feb7f5f94302af597b9d0d859e862021-09-05T21:02:06ZengSciendoInterdisciplinary Toxicology1337-95692014-09-017317317610.2478/intox-2014-0024intox-2014-0024High mortality due to accidental salinomycin intoxication in sheepAshrafihelan Javad0Eisapour Hamed1Erfani Amir Mehdi2Kalantary Amir Ali3Amoli Jamileh Salar4Mozafari Morteza5Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, IranVeterinary Organization, Zanjan, IranVeterinary Organization, Zanjan, IranVeterinary Organization, Zanjan, IranToxicology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranFaculty of Veterinary Medicine, University of Tabriz, Tabriz, IranIn February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran) had been added to the ration (22388 mg/kg = 22388 ppm) and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN) in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed.https://doi.org/10.2478/intox-2014-0024salinomycinsheepacute toxicosiscardiomyolysisacute tubular necrosisiran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashrafihelan Javad Eisapour Hamed Erfani Amir Mehdi Kalantary Amir Ali Amoli Jamileh Salar Mozafari Morteza |
spellingShingle |
Ashrafihelan Javad Eisapour Hamed Erfani Amir Mehdi Kalantary Amir Ali Amoli Jamileh Salar Mozafari Morteza High mortality due to accidental salinomycin intoxication in sheep Interdisciplinary Toxicology salinomycin sheep acute toxicosis cardiomyolysis acute tubular necrosis iran |
author_facet |
Ashrafihelan Javad Eisapour Hamed Erfani Amir Mehdi Kalantary Amir Ali Amoli Jamileh Salar Mozafari Morteza |
author_sort |
Ashrafihelan Javad |
title |
High mortality due to accidental salinomycin intoxication in sheep |
title_short |
High mortality due to accidental salinomycin intoxication in sheep |
title_full |
High mortality due to accidental salinomycin intoxication in sheep |
title_fullStr |
High mortality due to accidental salinomycin intoxication in sheep |
title_full_unstemmed |
High mortality due to accidental salinomycin intoxication in sheep |
title_sort |
high mortality due to accidental salinomycin intoxication in sheep |
publisher |
Sciendo |
series |
Interdisciplinary Toxicology |
issn |
1337-9569 |
publishDate |
2014-09-01 |
description |
In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran) had been added to the ration (22388 mg/kg = 22388 ppm) and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN) in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed. |
topic |
salinomycin sheep acute toxicosis cardiomyolysis acute tubular necrosis iran |
url |
https://doi.org/10.2478/intox-2014-0024 |
work_keys_str_mv |
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