Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

The establishment of separated pulmonary and systemic circulation in vertebrates, via cardiac outflow tract (OFT) septation, is a sensitive developmental process accounting for 10% of all congenital anomalies. Neural Crest Cells (NCC) colonising the heart condensate along the primitive endocardial t...

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Bibliographic Details
Main Authors: Jean-François Darrigrand, Mariana Valente, Glenda Comai, Pauline Martinez, Maxime Petit, Ryuichi Nishinakamura, Daniel S Osorio, Gilles Renault, Carmen Marchiol, Vanessa Ribes, Bruno Cadot
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
outflow tract
neural crest cells
Dullard
BMP signaling
mesenchymal-epithelial transition
Online Access:https://elifesciences.org/articles/50325

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