Fulminant Type 1 Diabetes in Children: A Multicenter Study in China
Background. To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. Methods. A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3....
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doaj-a791482dd717497984dca605975f08572020-11-24T23:42:24ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/69246376924637Fulminant Type 1 Diabetes in Children: A Multicenter Study in ChinaYi Gu0Yi Wang1Pin Li2Haiyan Wei3Linqi Chen4Qianqi Liu5Yu Liu6Qiaozhi Yang7Xinran Cheng8Lanjie He9Liya Wei10Zhiying Zhu11Yongxing Chen12Fengyun Wang13Xing Shi14Yuxian Cheng15Yan Wei16Jianing Yu17Chunxiu Gong18National Key Discipline of Pediatrics, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, ChinaNational Key Discipline of Pediatrics, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, ChinaDepartment of Endocrinology, Children’s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Endocrinology and Genetic Metabolism, Zhengzhou Children’s Hospital, Zhengzhou 450053, ChinaDepartment of Endocrinology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Endocrinology, Nanjing Children’s Hospital of Nanjing Medical University, Nanjing 210005, ChinaDepartment of Endocrinology, Genetics and Metabolism, The Children’s Hospital of Guiyang City, Guiyang 550003, ChinaDepartment of Pediatric, Liaocheng Children’s Hospital, Shandong 252002, ChinaThe Pediatric Endocrine Department, Chengdu Woman and Children’s Center Hospital, Chengdu 610091, ChinaDepartment of Pediatric, General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaNational Key Discipline of Pediatrics, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, ChinaDepartment of Endocrinology, Children’s Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200062, ChinaDepartment of Endocrinology and Genetic Metabolism, Zhengzhou Children’s Hospital, Zhengzhou 450053, ChinaDepartment of Endocrinology, Children’s Hospital of Soochow University, Suzhou 215003, ChinaDepartment of Endocrinology, Nanjing Children’s Hospital of Nanjing Medical University, Nanjing 210005, ChinaDepartment of Pediatric, Liaocheng Children’s Hospital, Shandong 252002, ChinaThe Pediatric Endocrine Department, Chengdu Woman and Children’s Center Hospital, Chengdu 610091, ChinaDepartment of Pediatric, General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaNational Key Discipline of Pediatrics, Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, ChinaBackground. To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. Methods. A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. Results. The incidence of FT1D was 1.56% in 16 participating hospitals. The mean age at the onset of group 1 was 2.00 (1.08, 6.51) years old, much younger than that of group 2 (6.11 (3.92, 9.50)) and group 3 (6.92 (4.17, 10.03)). In addition, significant differences were found between three groups: mean BMI and flu-like symptoms with fever and abdominal pain. Follow-up comparison of three groups from Beijing Children’s Hospital for at least one year showed that there is no significant difference between the three groups in terms of mean HbA1c levels and insulin injection dosages. Conclusion. FT1D onset age is much younger than that of classical T1D patients. The hospital-based incidence of FT1D in Chinese children was 1.56% in all new-onset T1DM. For the diagnosis, making FT1D alone into a subtype within type 1 diabetes may be meaningful. However, for the treatment and prognosis, such classification should not be helpful to the clinic.http://dx.doi.org/10.1155/2017/6924637 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Gu Yi Wang Pin Li Haiyan Wei Linqi Chen Qianqi Liu Yu Liu Qiaozhi Yang Xinran Cheng Lanjie He Liya Wei Zhiying Zhu Yongxing Chen Fengyun Wang Xing Shi Yuxian Cheng Yan Wei Jianing Yu Chunxiu Gong |
spellingShingle |
Yi Gu Yi Wang Pin Li Haiyan Wei Linqi Chen Qianqi Liu Yu Liu Qiaozhi Yang Xinran Cheng Lanjie He Liya Wei Zhiying Zhu Yongxing Chen Fengyun Wang Xing Shi Yuxian Cheng Yan Wei Jianing Yu Chunxiu Gong Fulminant Type 1 Diabetes in Children: A Multicenter Study in China Journal of Diabetes Research |
author_facet |
Yi Gu Yi Wang Pin Li Haiyan Wei Linqi Chen Qianqi Liu Yu Liu Qiaozhi Yang Xinran Cheng Lanjie He Liya Wei Zhiying Zhu Yongxing Chen Fengyun Wang Xing Shi Yuxian Cheng Yan Wei Jianing Yu Chunxiu Gong |
author_sort |
Yi Gu |
title |
Fulminant Type 1 Diabetes in Children: A Multicenter Study in China |
title_short |
Fulminant Type 1 Diabetes in Children: A Multicenter Study in China |
title_full |
Fulminant Type 1 Diabetes in Children: A Multicenter Study in China |
title_fullStr |
Fulminant Type 1 Diabetes in Children: A Multicenter Study in China |
title_full_unstemmed |
Fulminant Type 1 Diabetes in Children: A Multicenter Study in China |
title_sort |
fulminant type 1 diabetes in children: a multicenter study in china |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2017-01-01 |
description |
Background. To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. Methods. A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. Results. The incidence of FT1D was 1.56% in 16 participating hospitals. The mean age at the onset of group 1 was 2.00 (1.08, 6.51) years old, much younger than that of group 2 (6.11 (3.92, 9.50)) and group 3 (6.92 (4.17, 10.03)). In addition, significant differences were found between three groups: mean BMI and flu-like symptoms with fever and abdominal pain. Follow-up comparison of three groups from Beijing Children’s Hospital for at least one year showed that there is no significant difference between the three groups in terms of mean HbA1c levels and insulin injection dosages. Conclusion. FT1D onset age is much younger than that of classical T1D patients. The hospital-based incidence of FT1D in Chinese children was 1.56% in all new-onset T1DM. For the diagnosis, making FT1D alone into a subtype within type 1 diabetes may be meaningful. However, for the treatment and prognosis, such classification should not be helpful to the clinic. |
url |
http://dx.doi.org/10.1155/2017/6924637 |
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