Synthesis of Peptide-Immobilized Magnetic Beads, and Peptide Reactivity Assay for Assessing Skin Sensitization Utilizing Chromophore

Synthesis of Peptide-Immobilized Magnetic Beads, and Peptide Reactivity Assay for Assessing Skin Sensitization Utilizing Chromophore

DPRA (direct peptide reactivity assay) and ADRA (amino acid derivative reactivity assay), which are based on the biological events of skin sensitization, were developed as alternatives to the controversial animal experiments. These assays are described in the OECD (Organization for Economic Co-opera...

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Bibliographic Details
Main Authors: Hiroshi Miyazaki, Hikaru Takaishi, Hidefumi Ikeda, Hideto Ariumi, Yoshio Hamada, Kunihiko Yamashita, Kenji Usui
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Processes
Subjects:
skin sensitization
alternatives to animal testing
peptide synthesis
magnetic beads
DPRA
Online Access:https://www.mdpi.com/2227-9717/8/10/1257

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