Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR...

Full description

Bibliographic Details
Main Authors:	Nubia Boechat, Osvaldo A. Santos-Filho, Isabor C. Silva, Luiz C.S. Pinheiro
Format:	Article
Language:	English
Published:	MDPI AG 2011-09-01
Series:	Molecules
Subjects:	malaria sulfonamide trifluoromethyl dihydropteroate synthase DHPS
Online Access:	http://www.mdpi.com/1420-3049/16/9/8083/

id	doaj-a7b140427bd141c98e14489b620b2928
record_format	Article
spelling	doaj-a7b140427bd141c98e14489b620b29282020-11-24T22:25:16ZengMDPI AGMolecules1420-30492011-09-011698083809710.3390/molecules16098083Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial PrototypesNubia BoechatOsvaldo A. Santos-FilhoIsabor C. SilvaLuiz C.S. PinheiroA rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.http://www.mdpi.com/1420-3049/16/9/8083/malariasulfonamidetrifluoromethyldihydropteroate synthaseDHPS
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nubia Boechat Osvaldo A. Santos-Filho Isabor C. Silva Luiz C.S. Pinheiro
spellingShingle	Nubia Boechat Osvaldo A. Santos-Filho Isabor C. Silva Luiz C.S. Pinheiro Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes Molecules malaria sulfonamide trifluoromethyl dihydropteroate synthase DHPS
author_facet	Nubia Boechat Osvaldo A. Santos-Filho Isabor C. Silva Luiz C.S. Pinheiro
author_sort	Nubia Boechat
title	Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_short	Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_full	Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_fullStr	Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_full_unstemmed	Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
title_sort	design and synthesis of new n-(5-trifluoromethyl)-1h-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2011-09-01
description	A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.
topic	malaria sulfonamide trifluoromethyl dihydropteroate synthase DHPS
url	http://www.mdpi.com/1420-3049/16/9/8083/
work_keys_str_mv	AT nubiaboechat designandsynthesisofnewn5trifluoromethyl1h124triazol3ylbenzenesulfonamidesaspossibleantimalarialprototypes AT osvaldoasantosfilho designandsynthesisofnewn5trifluoromethyl1h124triazol3ylbenzenesulfonamidesaspossibleantimalarialprototypes AT isaborcsilva designandsynthesisofnewn5trifluoromethyl1h124triazol3ylbenzenesulfonamidesaspossibleantimalarialprototypes AT luizcspinheiro designandsynthesisofnewn5trifluoromethyl1h124triazol3ylbenzenesulfonamidesaspossibleantimalarialprototypes
_version_	1725758573418381312

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

Similar Items