Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria
Multiple scarce nutrients, such as iron and nickel, are essential for bacterial growth. Gram-negative bacteria secrete chelators to bind these nutrients from the environment competitively. The transport of the resulting complexes into bacterial cells is mediated by TonB-dependent transporters (TBDTs...
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2021-01-01
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doaj-a7c7fb3c4b5545049ad82a9ce5f60c0b2021-01-27T08:22:55ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-01-011010.3389/fcimb.2020.589115589115Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative BacteriaJia Wang0Kun Xiong1Qu Pan2Weifeng He3Yanguang Cong4Yanguang Cong5Department of Clinical Laboratory, Traditional Medicine Hospital Affiliated to Southwest Medical University, Luzhou, ChinaDepartment of Cold Environmental Medicine, Institute of High Altitude Military Medicine, Army Medical University, Chongqiong, ChinaDepartment of Microbiology, Chengdu Medical College, Chengdu, ChinaDepartment of Burn, Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Clinical Laboratory, Traditional Medicine Hospital Affiliated to Southwest Medical University, Luzhou, ChinaPrecision Medicine Center, Traditional Medicine Hospital Affiliated to Southwest Medical University, Luzhou, ChinaMultiple scarce nutrients, such as iron and nickel, are essential for bacterial growth. Gram-negative bacteria secrete chelators to bind these nutrients from the environment competitively. The transport of the resulting complexes into bacterial cells is mediated by TonB-dependent transporters (TBDTs) located at the outer membrane in Gram-negative bacteria. The characteristics of TBDTs, including surface exposure, protective immunogenicity, wide distribution, inducible expression in vivo, and essential roles in pathogenicity, make them excellent candidates for vaccine development. The possible application of a large number of TBDTs in immune control of the corresponding pathogens has been recently investigated. This paper summarizes the latest progresses and current major issues in the application.https://www.frontiersin.org/articles/10.3389/fcimb.2020.589115/fullTonB-dependent transportervaccineinfectionGram-negative bacteriaimmune |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia Wang Kun Xiong Qu Pan Weifeng He Yanguang Cong Yanguang Cong |
spellingShingle |
Jia Wang Kun Xiong Qu Pan Weifeng He Yanguang Cong Yanguang Cong Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria Frontiers in Cellular and Infection Microbiology TonB-dependent transporter vaccine infection Gram-negative bacteria immune |
author_facet |
Jia Wang Kun Xiong Qu Pan Weifeng He Yanguang Cong Yanguang Cong |
author_sort |
Jia Wang |
title |
Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria |
title_short |
Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria |
title_full |
Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria |
title_fullStr |
Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria |
title_full_unstemmed |
Application of TonB-Dependent Transporters in Vaccine Development of Gram-Negative Bacteria |
title_sort |
application of tonb-dependent transporters in vaccine development of gram-negative bacteria |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-01-01 |
description |
Multiple scarce nutrients, such as iron and nickel, are essential for bacterial growth. Gram-negative bacteria secrete chelators to bind these nutrients from the environment competitively. The transport of the resulting complexes into bacterial cells is mediated by TonB-dependent transporters (TBDTs) located at the outer membrane in Gram-negative bacteria. The characteristics of TBDTs, including surface exposure, protective immunogenicity, wide distribution, inducible expression in vivo, and essential roles in pathogenicity, make them excellent candidates for vaccine development. The possible application of a large number of TBDTs in immune control of the corresponding pathogens has been recently investigated. This paper summarizes the latest progresses and current major issues in the application. |
topic |
TonB-dependent transporter vaccine infection Gram-negative bacteria immune |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2020.589115/full |
work_keys_str_mv |
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