Evaluation of Brāhmī ghṛtam in children suffering from Attention Deficit Hyperactivity Disorder

• Main Authors: Supriya Bhalerao, Renuka Munshi, Tanuja Nesari, Heenal Shah
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Ancient Science of Life
• Subjects: Dupaul Attention Deficit Hyperactivity Disorder rating scale; psychometry
• Online Access: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=33;issue=2;spage=123;epage=130;aulast=Bhalerao

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity. In view of the adverse effects associated with psycho-stimulants used for the treatment of this disorder, efficacy of Brāhmīghṛtam was evaluated in this condition. Materials and Methods: After following due ethical considerations, children of either sex between the age group of 6 and 12 years diagnosed to be suffering from mixed variety of ADHD as per The Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria irrespective of other co-morbid psychiatric illnesses were recruited in the study. Initially a pilot study (n = 10) was carried out to confirm the efficacy of the identified dose of Brāhmīghṛtam. Using this dose, further therapeutic confirmatory study (n = 27) was carried out, wherein Brāhmīghṛtam was compared with methylphenidate. Effect on ADHD symptoms was assessed using the Dupaul ADHD rating scale and this was the main efficacy parameter. Results: In the pilot exploratory study, Brāhmīghṛtam showed 66% decrease in total ADHD score. In the therapeutic confirmatory study, only 16% improvement was seen with Brāhmīghṛtam, which was similar to methylphenidate, standard treatment for ADHD that was used as a comparator in the present study. No side-effects were reported in both studies. Conclusion: Our study thus has adequately demonstrated efficacy and safety of Brāhmīghṛtam in ADHD.