Trabecular Bone Score and Bone Mineral Density in Men with Vertebral Fractures

• Main Authors: V.V. Povoroznyk, A.S. Musiienko, N.I. Dzerovych
• Format: Article
• Language: English
• Published: Zaslavsky O.Yu. 2015-02-01
• Series: Bolʹ, Sustavy, Pozvonočnik
• Subjects: trabecular bone score; bone mineral density; men; vertebral fractures
• Online Access: http://pjs.zaslavsky.com.ua/article/view/79019
• ISSN: 2224-1507; 2307-1133

Traditionally bone mineral density (BMD) has been considered a major determinant of bone strength. However, it is shown that the bone strength and fracture risk depend on several parameters: macrogeometry of cortical bone, BMD, trabecular bone microarchitecture, bone microdamages, bone mineralization, and bone metabolism. Previous studies have found that trabecular bone score (TBS) significantly decreases in men with age, but TBS hadn’t been studied yet in Ukrainian men with fractures, in particular vertebral fractures. The objective of this study is to evaluate the trabecular bone score and bone mineral density in men with vertebral fractures. We’ve examined 243 men aged 30–89 years, divided according to the gerontological classification: 30–44 yrs (n = 46), 45–59 yrs (n = 83), 60–74 yrs (n = 86), 75–89 yrs (n = 28). The main group consists of 52 men with the history of low-energy vertebral fractures (mean age — 59.8 ± 13.7 yrs, mean height — 1.73 ± 6.98 m, mean weight — 79.0 ± 14.9 kg), control group — of 191 men without fractures (mean age — 57.4 ± 13.7 yrs, mean height — 1.74 ± 6.89 m, mean weight — 76.5 ± 9.3 kg). Using dual-energy X-ray absorptiometry (Prodigy, GE Lunar, Madison, USA), we have studied BMD of lumbar spine (L1-L4), femoral neck, total skeleton and ultradistal forearm bones. TBS indicator in lumbar spine (L1-L4) was determined by the method of TBS iNsight (Med-Imaps, Pessac, France). As a result, the study found that TBS (L1-L4) was significantly lower in the main group (30–44 yrs — 1.083 ± 0.187, 45–59 yrs — 1.025 ± 0.248, 60–74 yrs — 1.084 ± 0.170, 75–89 yrs — 0.951 ± 0.170) as compared to the control group (30–44 yrs — 1.276 ± 0.121, 45–59 yrs — 1.226 ± 0.156, 60–74 yrs — 1.150 ± 0.175, 75–89 yrs — 1.183 ± 0.174); F = 1.56; p < 0.001. BMD of lumbar spine (F = 1.52; p < 0.001) and femoral neck (F = 1.10; p < 0.001) was also significantly lower in the main group compared with the control one.