A Case Report of a Gingival Plasma Cell Granuloma in a Patient on Antihypertensive Therapy: Diagnostic Enigma

• Main Authors: Ruchi Gulati, Madhu Singh Ratre, Shaleen Khetarpal, Manish Varma
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2019-04-01
• Series: Frontiers in Dentistry
• Subjects: amlodipine; diagnosis; gingival overgrowth; plasma cells; plasma cell granuloma
• Online Access: https://fid.tums.ac.ir/index.php/jdt/article/view/2440

The aim of the present report was to discuss a unique case of gingival plasma cell granuloma (PCG) in a hypertensive patient on Amlodipine therapy. Also, we attempt to emphasize the importance of considering primary and advance investigations before making a definite diagnosis. PCG is an extremely rare, reactive, non-neoplastic lesion characterized by the predominance of polyclonal plasma cells. Drug-induced gingival overgrowth is a known side effect of Amlodipine. A hypertensive 60-year-old female patient reported with a chief complaint of swollen gums and discomfort in the upper front teeth region. A provisional diagnosis of Amlodipine-induced gingival overgrowth, combined gingival overgrowth, and fibroma was suggested. Surprisingly, histopathology revealed it to be a plasma cell lesion which was confirmed by advanced investigations, thereby establishing a confirmatory diagnosis of PCG.