A case report: acute pancreatitis associated with tacrolimus in kidney transplantation
Abstract Background Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously. Case presen...
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doaj-a7d595e18dfe4b6b82ce797422a92f482020-11-25T03:03:20ZengBMCBMC Nephrology1471-23692019-06-012011310.1186/s12882-019-1395-xA case report: acute pancreatitis associated with tacrolimus in kidney transplantationJunnan Xu0Liang Xu1Xing Wei2Xiang Li3Ming Cai4Organ Transplant Institute of People’s Liberation Army, the 309th Hospital of People’s Liberation ArmyOrgan Transplant Institute of People’s Liberation Army, the 309th Hospital of People’s Liberation ArmyOrgan Transplant Institute of People’s Liberation Army, the 309th Hospital of People’s Liberation ArmyOrgan Transplant Institute of People’s Liberation Army, the 309th Hospital of People’s Liberation ArmyOrgan Transplant Institute of People’s Liberation Army, the 309th Hospital of People’s Liberation ArmyAbstract Background Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously. Case presentation Here we presented a case of a 45-year-old male who underwent kidney transplantation and received immunosuppressive therapy of tacrolimus, on day + 67 after transplantation he developed acute pancreatitis with extremely high blood concentration of tacrolimus. We excluded other possible causes and speculated tacrolimus was the probable inducer of pancreatitis. After tacrolimus was discontinued and alternated with cyclosporine, he gradually recovered and was discharged home with no relapse. Conclusion Tacrolimus can be a probable cause of pancreatitis after kidney transplantation. We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment.http://link.springer.com/article/10.1186/s12882-019-1395-xAcute pancreatitisTacrolimusFK506Kidney transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junnan Xu Liang Xu Xing Wei Xiang Li Ming Cai |
spellingShingle |
Junnan Xu Liang Xu Xing Wei Xiang Li Ming Cai A case report: acute pancreatitis associated with tacrolimus in kidney transplantation BMC Nephrology Acute pancreatitis Tacrolimus FK506 Kidney transplantation |
author_facet |
Junnan Xu Liang Xu Xing Wei Xiang Li Ming Cai |
author_sort |
Junnan Xu |
title |
A case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
title_short |
A case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
title_full |
A case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
title_fullStr |
A case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
title_full_unstemmed |
A case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
title_sort |
case report: acute pancreatitis associated with tacrolimus in kidney transplantation |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2019-06-01 |
description |
Abstract Background Tacrolimus has been widely used for immunosuppressive therapy in solid organ transplantation (SOT) and allo-geneic stem cell transplantation (allo-SCT) over the past 2 decades. Pancreatitis caused by tacrolimus was rarely reported in kidney transplantation previously. Case presentation Here we presented a case of a 45-year-old male who underwent kidney transplantation and received immunosuppressive therapy of tacrolimus, on day + 67 after transplantation he developed acute pancreatitis with extremely high blood concentration of tacrolimus. We excluded other possible causes and speculated tacrolimus was the probable inducer of pancreatitis. After tacrolimus was discontinued and alternated with cyclosporine, he gradually recovered and was discharged home with no relapse. Conclusion Tacrolimus can be a probable cause of pancreatitis after kidney transplantation. We recommended clinicians to be aware of the possibility of tacrolimus-induced pancreatitis during tacrolimus treatment. |
topic |
Acute pancreatitis Tacrolimus FK506 Kidney transplantation |
url |
http://link.springer.com/article/10.1186/s12882-019-1395-x |
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