Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function. Dysregulated PTMs may influence the propensity for protein aggregation in NDD-proteinopathies. To inv...

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Bibliographic Details
Main Authors: Larissa-Nele Schaffert, Wayne G. Carter
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Brain Sciences
Subjects:
neurodegenerative diseases
neurotoxicity
post-translational modifications
protein aggregates
Online Access:https://www.mdpi.com/2076-3425/10/4/232

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