Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis
Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...
Main Authors: | Constance C. Angelou, Alexandria C. Wells, Jyothi Vijayaraghavan, Carey E. Dougan, Rebecca Lawlor, Elizabeth Iverson, Vanja Lazarevic, Motoko Y. Kimura, Shelly R. Peyton, Lisa M. Minter, Barbara A. Osborne, Elena L. Pobezinskaya, Leonid A. Pobezinsky |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-01-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.03125/full |
Similar Items
-
Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice
by: Takako Takemiya, et al.
Published: (2017-10-01) -
Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis
by: Antonietta Gentile, et al.
Published: (2015-02-01) -
IL18 signaling promotes homing of mature Tregs into the thymus
by: Cristina Peligero-Cruz, et al.
Published: (2020-07-01) -
IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease
by: Kim Byung S, et al.
Published: (2012-09-01) -
Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
by: Levi Todd, et al.
Published: (2019-06-01)