Three-dimensionally Specific Inhibition of DNA Repair-Related Genes by Activated KRAS in Colon Crypt Model
Growth and differentiation of colonic epithelium are regulated in the three-dimensional (3D) physiological architecture, colonic crypt, and deregulation of 3D interactions is involved in tumorigenesis. Cell-based 3D culture systems provide a suitable approach bridging the gap between two-dimensiona...
Main Authors: | Toshiyuki Tsunoda, Yasuo Takashima, Takahiro Fujimoto, Midori Koyanagi, Yasuhiro Yoshida, Keiko Doi, Yoko Tanaka, Masahide Kuroki, Takehiko Sasazuki, Senji Shirasawa |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2010-05-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558610800570 |
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