Clinical and biochemical predictors of late-outcome in patients after ischemic stroke

• Main Authors: Joanna Ewa Bielewicz, Jacek Kurzepa, Piotr Kamieniak, Beata Daniluk, Anna Szczepańska-Szerej, Konrad Rejdak
• Format: Article
• Language: English
• Published: Institute of Rural Health 2020-06-01
• Series: Annals of Agricultural and Environmental Medicine
• Subjects: crp; outcome; ischemic stroke; mrs; barthel index; nihss
• Online Access: http://www.journalssystem.com/aaem/Clinical-and-biochemical-predictors-of-late-outcome-in-patients-after-ischemic-stroke,105927,0,2.html
• ISSN: 1232-1966; 1898-2263

Objective The aim of this study is to evaluate neurological scales, as well as biochemical and radiological parameters measured on day 10 after ischemic stroke (IS), according to their value as predictors of the long-term outcome. Material and methods 45 patients were assessed according to the Barthel Index (BI) and National Institute of Health Stroke Scale (NIHSS) on day 10, and according to Modified Rankin Scale (mRS) 3 months after the onset of IS. On day 10 of IS, the serum level of C-reactive protein (CRP), albumin, D-dimers (DD), S100BB and Tau proteins was measured and the volume of ischemic focus assessed with the use of Computed Tomography (CT). The patients were divided into groups with good outcome (GO) and mRS 0–2, and with bad outcome (BO) and mRS 3–6. Results NIHSS and BI scores (p<0.001), the volume of ischemic focus (p<0.01), CRP (p<0.01) and albumin level (p<0.05), but not DD, S100BB and Tau protein levels evaluated on day 10, correlated with mRS after 3 months since IS onset. Patients from the BO group were observed to have lower BI (p=0.001), higher NIHSS (p<0.01) and CRP levels (p<0.05), and bigger volume of ischemic focus (p<0.05) measured on day 10 of IS. In the GO group, there were more patients with atherosclerotic etiology (p=0.02 x2=7.856). Regression analysis showed that only the BI score assessed on day 10 of IS can predict the outcome after 3 months assessed by mRS (OR=1.102, 95%, CI:1.01–1.203; p=0.001). Conclusions BI assessed on day 10 has a predictive value for the outcome evaluated by mRS 3 months after the onset of IS.