Interests of the Non-Human Primate Models for HIV Cure Research
Non-human primate (NHP) models are important for vaccine development and also contribute to HIV cure research. Although none of the animal models are perfect, NHPs enable the exploration of important questions about tissue viral reservoirs and the development of intervention strategies. In this revi...
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MDPI AG
2021-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/9/958 |
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doaj-a7fe0adb6c01493db72af9800a8a0c222021-09-26T01:35:29ZengMDPI AGVaccines2076-393X2021-08-01995895810.3390/vaccines9090958Interests of the Non-Human Primate Models for HIV Cure ResearchGauthier Terrade0Nicolas Huot1Caroline Petitdemange2Marie Lazzerini3Aurelio Orta Resendiz4Beatrice Jacquelin5Michaela Müller-Trutwin6Institut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceInstitut Pasteur, Unité HIV, Inflammation et Persistance, 75015 Paris, FranceNon-human primate (NHP) models are important for vaccine development and also contribute to HIV cure research. Although none of the animal models are perfect, NHPs enable the exploration of important questions about tissue viral reservoirs and the development of intervention strategies. In this review, we describe recent advances in the use of these models for HIV cure research and highlight the progress that has been made as well as limitations using these models. The main NHP models used are (i) the macaque, in which simian immunodeficiency virus (SIVmac) infection displays similar replication profiles as to HIV in humans, and (ii) the macaque infected by a recombinant virus (SHIV) consisting of SIVmac expressing the HIV envelope gene serving for studies analyzing the impact of anti-HIV Env broadly neutralizing antibodies. Lessons for HIV cure that can be learned from studying the natural host of SIV are also presented here. An overview of the most promising and less well explored HIV cure strategies tested in NHP models will be given.https://www.mdpi.com/2076-393X/9/9/958animal modelnon-human primateHIVSIVnatural hostcure |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gauthier Terrade Nicolas Huot Caroline Petitdemange Marie Lazzerini Aurelio Orta Resendiz Beatrice Jacquelin Michaela Müller-Trutwin |
| spellingShingle |
Gauthier Terrade Nicolas Huot Caroline Petitdemange Marie Lazzerini Aurelio Orta Resendiz Beatrice Jacquelin Michaela Müller-Trutwin Interests of the Non-Human Primate Models for HIV Cure Research Vaccines animal model non-human primate HIV SIV natural host cure |
| author_facet |
Gauthier Terrade Nicolas Huot Caroline Petitdemange Marie Lazzerini Aurelio Orta Resendiz Beatrice Jacquelin Michaela Müller-Trutwin |
| author_sort |
Gauthier Terrade |
| title |
Interests of the Non-Human Primate Models for HIV Cure Research |
| title_short |
Interests of the Non-Human Primate Models for HIV Cure Research |
| title_full |
Interests of the Non-Human Primate Models for HIV Cure Research |
| title_fullStr |
Interests of the Non-Human Primate Models for HIV Cure Research |
| title_full_unstemmed |
Interests of the Non-Human Primate Models for HIV Cure Research |
| title_sort |
interests of the non-human primate models for hiv cure research |
| publisher |
MDPI AG |
| series |
Vaccines |
| issn |
2076-393X |
| publishDate |
2021-08-01 |
| description |
Non-human primate (NHP) models are important for vaccine development and also contribute to HIV cure research. Although none of the animal models are perfect, NHPs enable the exploration of important questions about tissue viral reservoirs and the development of intervention strategies. In this review, we describe recent advances in the use of these models for HIV cure research and highlight the progress that has been made as well as limitations using these models. The main NHP models used are (i) the macaque, in which simian immunodeficiency virus (SIVmac) infection displays similar replication profiles as to HIV in humans, and (ii) the macaque infected by a recombinant virus (SHIV) consisting of SIVmac expressing the HIV envelope gene serving for studies analyzing the impact of anti-HIV Env broadly neutralizing antibodies. Lessons for HIV cure that can be learned from studying the natural host of SIV are also presented here. An overview of the most promising and less well explored HIV cure strategies tested in NHP models will be given. |
| topic |
animal model non-human primate HIV SIV natural host cure |
| url |
https://www.mdpi.com/2076-393X/9/9/958 |
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