Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

Baicalin Protects Against 17α-Ethinylestradiol-Induced Cholestasis via the Sirtuin 1/Hepatic Nuclear Receptor-1α/Farnesoid X Receptor Pathway

Estrogen-induced cholestasis (EIC) is characterized by impairment of bile flow and accumulated bile acids (BAs) in the liver, always along with the liver damage. Baicalin is a major flavonoid component of Scutellaria baicalensis, and has been used in the treatment of liver diseases for many years. H...

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Bibliographic Details
Main Authors: Jinyu Yang, Daochun Xiang, Dong Xiang, Wenxi He, Yanan Liu, Lulu Lan, Guodong Li, Chen Jiang, Xiuhua Ren, Dong Liu, Chengliang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
baiclain
cholestasis
17α-ethinylestradiol
sirtuin 1
hepatic nuclear receptor-1α
farnesoid X receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01685/full

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