Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein
The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibody termed mAb P-4G2, which neutralizes the zoonotic...
Main Authors: | Ilona Rissanen, Robert Stass, Stefanie A Krumm, Jeffrey Seow, Ruben JG Hulswit, Guido C Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J Doores, Juha T Huiskonen, Thomas A Bowden |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/58242 |
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