CrisPam: SNP-Derived PAM Analysis Tool for Allele-Specific Targeting of Genetic Variants Using CRISPR-Cas Systems

CrisPam: SNP-Derived PAM Analysis Tool for Allele-Specific Targeting of Genetic Variants Using CRISPR-Cas Systems

Clustered regularly interspaced short palindromic repeats (CRISPR) is a promising novel technology that holds the potential of treating genetic diseases. Safety and specificity of the treatment are to be further studied and developed prior to implementation of the technology into the clinic. The gui...

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Bibliographic Details
Main Authors: Roy Rabinowitz, Shiri Almog, Roy Darnell, Daniel Offen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
CrisPam
allele-specific
clustered regularly interspaced short palindromic repeats
single-nucleotide polymorphism-derived protospacer adjacent motif
guide RNA design
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00851/full

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