Emerging role of human polyomaviruses 6 and 7 in human cancers

• Main Authors: Faisal Klufah, Ghalib Mobaraki, Dan Liu, Raed A. Alharbi, Anna Kordelia Kurz, Ernst Jan M. Speel, Véronique Winnepenninckx, Axel zur Hausen
• Format: Article
• Language: English
• Published: BMC 2021-05-01
• Series: Infectious Agents and Cancer
• Subjects: HPyV6; HPyV7; Merkel cell polyomavirus; Oncogenic viruses; Cutaneous tumors; Viral persistence
• Online Access: https://doi.org/10.1186/s13027-021-00374-3

Abstract Background Currently 12 human polyomaviruses (HPyVs) have been identified, 6 of which have been associated with human diseases, including cancer. The discovery of the Merkel cell polyomavirus and its role in the etiopathogenesis in the majority of Merkel cell carcinomas has drawn significant attention, also to other novel HPyVs. In 2010, HPyV6 and HPyV7 were identified in healthy skin swabs. Ever since it has been speculated that they might contribute to the etiopathogenesis of skin and non-cutaneous human cancers. Main body Here we comprehensively reviewed and summarized the current evidence potentially indicating an involvement of HPyV6 and HPyV7 in the etiopathogenesis of neoplastic human diseases. The seroprevalence of both HPyV6 and 7 is high in a normal population and increases with age. In skin cancer tissues, HPyV6- DNA was far more often prevalent than HPyV7 in contrast to cancers of other anatomic sites, in which HPyV7 DNA was more frequently detected. Conclusion It is remarkable to find that the detection rate of HPyV6-DNA in tissues of skin malignancies is higher than HPyV7-DNA and may indicate a role of HPyV6 in the etiopathogenesis of the respected skin cancers. However, the sheer presence of viral DNA is not enough to prove a role in the etiopathogenesis of these cancers.