Health-Related Quality of Life and Frailty in Chronic Liver Diseases
We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (<i>n </i>= 341, 122 liver cirrhosis cases, median age = 66 years). Frai...
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Format: | Article |
Language: | English |
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MDPI AG
2020-05-01
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Series: | Life |
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Online Access: | https://www.mdpi.com/2075-1729/10/5/76 |
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doaj-a844fef499b34802842963256a74272f |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroki Nishikawa Kazunori Yoh Hirayuki Enomoto Yoshinori Iwata Yoshiyuki Sakai Kyohei Kishino Yoshihiro Shimono Naoto Ikeda Tomoyuki Takashima Nobuhiro Aizawa Ryo Takata Kunihiro Hasegawa Takashi Koriyama Yukihisa Yuri Takashi Nishimura Shuhei Nishiguchi Hiroko Iijima |
spellingShingle |
Hiroki Nishikawa Kazunori Yoh Hirayuki Enomoto Yoshinori Iwata Yoshiyuki Sakai Kyohei Kishino Yoshihiro Shimono Naoto Ikeda Tomoyuki Takashima Nobuhiro Aizawa Ryo Takata Kunihiro Hasegawa Takashi Koriyama Yukihisa Yuri Takashi Nishimura Shuhei Nishiguchi Hiroko Iijima Health-Related Quality of Life and Frailty in Chronic Liver Diseases Life chronic liver disease health-related quality of life SF-36 frailty |
author_facet |
Hiroki Nishikawa Kazunori Yoh Hirayuki Enomoto Yoshinori Iwata Yoshiyuki Sakai Kyohei Kishino Yoshihiro Shimono Naoto Ikeda Tomoyuki Takashima Nobuhiro Aizawa Ryo Takata Kunihiro Hasegawa Takashi Koriyama Yukihisa Yuri Takashi Nishimura Shuhei Nishiguchi Hiroko Iijima |
author_sort |
Hiroki Nishikawa |
title |
Health-Related Quality of Life and Frailty in Chronic Liver Diseases |
title_short |
Health-Related Quality of Life and Frailty in Chronic Liver Diseases |
title_full |
Health-Related Quality of Life and Frailty in Chronic Liver Diseases |
title_fullStr |
Health-Related Quality of Life and Frailty in Chronic Liver Diseases |
title_full_unstemmed |
Health-Related Quality of Life and Frailty in Chronic Liver Diseases |
title_sort |
health-related quality of life and frailty in chronic liver diseases |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2020-05-01 |
description |
We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (<i>n </i>= 341, 122 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: <26 kg in men and <18 kg in women), slow walking speed (<1.0 m/s), and low physical activity. Robust (frailty score 0), prefrail (frailty score 1 or 2), and frailty were found in 108 (31.7%), 187 (54.8%), and 46 (13.5%) patients, respectively. In all eight scales of the SF-36 (physical functioning, role physical, bodily pain, general health perception, vitality, social functioning, role emotion, and mental health), and the physical component summary score and mental component summary score, each score was well stratified according to the frailty status (all <i>p </i>< 0.0001). In the multivariate analysis, age (<i>p </i>= 0.0126), physical functioning (<i>p </i>= 0.0005), and vitality (<i>p </i>= 0.0246) were independent predictors linked to the presence of frailty. In conclusion, Japanese CLD patients with frailty displayed poorer conditions, both physically and mentally. |
topic |
chronic liver disease health-related quality of life SF-36 frailty |
url |
https://www.mdpi.com/2075-1729/10/5/76 |
work_keys_str_mv |
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spelling |
doaj-a844fef499b34802842963256a74272f2020-11-25T02:49:01ZengMDPI AGLife2075-17292020-05-0110767610.3390/life10050076Health-Related Quality of Life and Frailty in Chronic Liver DiseasesHiroki Nishikawa0Kazunori Yoh1Hirayuki Enomoto2Yoshinori Iwata3Yoshiyuki Sakai4Kyohei Kishino5Yoshihiro Shimono6Naoto Ikeda7Tomoyuki Takashima8Nobuhiro Aizawa9Ryo Takata10Kunihiro Hasegawa11Takashi Koriyama12Yukihisa Yuri13Takashi Nishimura14Shuhei Nishiguchi15Hiroko Iijima16Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanKano General Hospital, Osaka 531-0041, JapanDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, JapanWe sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (<i>n </i>= 341, 122 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: <26 kg in men and <18 kg in women), slow walking speed (<1.0 m/s), and low physical activity. Robust (frailty score 0), prefrail (frailty score 1 or 2), and frailty were found in 108 (31.7%), 187 (54.8%), and 46 (13.5%) patients, respectively. In all eight scales of the SF-36 (physical functioning, role physical, bodily pain, general health perception, vitality, social functioning, role emotion, and mental health), and the physical component summary score and mental component summary score, each score was well stratified according to the frailty status (all <i>p </i>< 0.0001). In the multivariate analysis, age (<i>p </i>= 0.0126), physical functioning (<i>p </i>= 0.0005), and vitality (<i>p </i>= 0.0246) were independent predictors linked to the presence of frailty. In conclusion, Japanese CLD patients with frailty displayed poorer conditions, both physically and mentally.https://www.mdpi.com/2075-1729/10/5/76chronic liver diseasehealth-related quality of lifeSF-36frailty |