Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway

Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway

Abstract Background Cisplatin (CDDP) is an effective anticancer drug for Gastric cancer (GC) that induces apoptosis by altering pro- (p53) and anti-apoptotic (Akt and NFkB) proteins; however, chemoresistance remains a big challenge. Additional compounds with promising anticancer effects such as AKBA...

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Bibliographic Details
Main Authors: Shadia Al-Bahlani, Ikram A. Burney, Buthaina Al-Dhahli, Safiya Al-Kharusi, Fakhra Al-Kharousi, Amani Al-Kalbani, Ikhlas Ahmed
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Pharmacology and Toxicology
Subjects:
P53
CDDP
AKBA
Apoptosis and gastric cancer
Online Access:http://link.springer.com/article/10.1186/s40360-020-00442-1

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