Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of connective tissue related to changes in lipid profile and lipoprotein metabolism. Studies show that the genetic polymorphism of PvuII low density lipoprotein receptor (LDLR) is associated with different concentrations of low den...
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Universidade Estadual de Londrina
2014-10-01
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Online Access: | http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19187 |
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doaj-a85408b4a6de4798b31c5e8b237162772020-11-24T22:21:09ZengUniversidade Estadual de LondrinaSemina : Ciências Biológicas e da Saúde1676-54351679-03672014-10-01361Supl10912210.5433/1679-0367.2015v36n1Suplp10911044Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosusJuliana Elisa Lima0Marcell Alysson Batisi Lozovoy1Daniela Frizon Alfieri2Francieli Delongui3Ana Paula Kallaur4Edna Maria Vissoci Reiche5Elaine Regina Delicato Almeida6Universidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaSystemic lupus erythematosus (SLE) is a chronic inflammatory disease of connective tissue related to changes in lipid profile and lipoprotein metabolism. Studies show that the genetic polymorphism of PvuII low density lipoprotein receptor (LDLR) is associated with different concentrations of low density lipoprotein (LDL) in general population. The present study evaluated the genetic polymorphism of PvuII LDLR and lipid profile in patients with SLE in southern Brazilian population. We included 72 patients with SLE and 154 blood donors. In assessing the lipid profile, SLE patients had elevated serum triglycerides (TG) levels compared with the control group (p 0.05). Patients with SLE and P1P1 genotype tended to have higher levels of TG compared with patients with SLE and P1P2 + P2P2 genotype (p = 0.0687). We conclude that genetic polymorphism may contribute to increased cardiovascular risk, however, the complexity of genetic components and disease evaluated should be taken into consideration. Further investigations are needed for other genes that may be involved in altering the lipid profile in this population.http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19187Lúpus eritematoso sistêmicoDislipidemiasPolimorfismo genético |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juliana Elisa Lima Marcell Alysson Batisi Lozovoy Daniela Frizon Alfieri Francieli Delongui Ana Paula Kallaur Edna Maria Vissoci Reiche Elaine Regina Delicato Almeida |
spellingShingle |
Juliana Elisa Lima Marcell Alysson Batisi Lozovoy Daniela Frizon Alfieri Francieli Delongui Ana Paula Kallaur Edna Maria Vissoci Reiche Elaine Regina Delicato Almeida Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus Semina : Ciências Biológicas e da Saúde Lúpus eritematoso sistêmico Dislipidemias Polimorfismo genético |
author_facet |
Juliana Elisa Lima Marcell Alysson Batisi Lozovoy Daniela Frizon Alfieri Francieli Delongui Ana Paula Kallaur Edna Maria Vissoci Reiche Elaine Regina Delicato Almeida |
author_sort |
Juliana Elisa Lima |
title |
Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus |
title_short |
Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus |
title_full |
Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus |
title_fullStr |
Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus |
title_full_unstemmed |
Evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (LDLR) in patients with systemic lupus erythematosus |
title_sort |
evaluation of genetic polymorphism pvuii of low density lipoprotein receptor (ldlr) in patients with systemic lupus erythematosus |
publisher |
Universidade Estadual de Londrina |
series |
Semina : Ciências Biológicas e da Saúde |
issn |
1676-5435 1679-0367 |
publishDate |
2014-10-01 |
description |
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of connective tissue related to changes in lipid profile and lipoprotein metabolism. Studies show that the genetic polymorphism of PvuII low density lipoprotein receptor (LDLR) is associated with different concentrations of low density lipoprotein (LDL) in general population. The present study evaluated the genetic polymorphism of PvuII LDLR and lipid profile in patients with SLE in southern Brazilian population. We included 72 patients with SLE and 154 blood donors. In assessing the lipid profile, SLE patients had elevated serum triglycerides (TG) levels compared with the control group (p 0.05). Patients with SLE and P1P1 genotype tended to have higher levels of TG compared with patients with SLE and P1P2 + P2P2 genotype (p = 0.0687). We conclude that genetic polymorphism may contribute to increased cardiovascular risk, however, the complexity of genetic components and disease evaluated should be taken into consideration. Further investigations are needed for other genes that may be involved in altering the lipid profile in this population. |
topic |
Lúpus eritematoso sistêmico Dislipidemias Polimorfismo genético |
url |
http://www.uel.br/revistas/uel/index.php/seminabio/article/view/19187 |
work_keys_str_mv |
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