Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells

Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells

Background/Aims: Neuroinflammatory processes have been implicated in the pathophysiology of seizure/epilepsy. High mobility group box 1 (HMGB1), a non-histone DNA binding protein, behaves like an inflammatory cytokine in response to epileptogenic insults. Kainic acid (KA) is an excitotoxic reagent c...

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Bibliographic Details
Main Authors: Yuji Kaneko, Colleen Pappas, Teresita Malapira, Fernando Ĺ. Vale, Naoki Tajiri, Cesar V. Borlongan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Epilepsy
HMGB1
Kainic acid
Primary rat neural cells
Glutamate
GABA
Online Access:http://www.karger.com/Article/FullText/460513

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http://www.karger.com/Article/FullText/460513

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