Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy
Background: Age is an important and objective risk factor for upper gastrointestinal (GI) malignancy. The accuracy of various age limits to detect upper GI malignancy is unclear. Determination of this accuracy may aid in the decision to refer symptomatic patients for upper GI endoscopy. The aim of t...
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2020-11-01
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Series: | Therapeutic Advances in Gastroenterology |
Online Access: | https://doi.org/10.1177/1756284820959225 |
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doaj-a8576e3a1df4462192976ef6b11f7fbe2020-11-25T03:07:22ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482020-11-011310.1177/1756284820959225Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopyJudith J. de JongMarten A. LantingaIna M. E. ThijsPhilip R. de ReuverJoost P. H. DrenthBackground: Age is an important and objective risk factor for upper gastrointestinal (GI) malignancy. The accuracy of various age limits to detect upper GI malignancy is unclear. Determination of this accuracy may aid in the decision to refer symptomatic patients for upper GI endoscopy. The aim of this analysis was to synthesize data on upper GI malignancy detection rates for various age limits worldwide through meta-analysis. Methods: We searched MEDLINE, EMBASE, and Web of Science in November 2018. Selection criteria included studies addressing malignant findings at upper GI endoscopy in a symptomatic population reporting age at time of diagnosis. Meta-analyses were conducted to derive continent-specific cancer detection rates. Results: A total of 33 studies including 346,641 patients across 21 countries fulfilled the inclusion criteria. To detect >80% of malignant cases all symptomatic patients over 40 years of age should be investigated in Africa, over 50 years of age in South America and Asia, and over 55 years of age in North America and Europe. Conclusion: This systematic review and meta-analysis provides data on intercontinental variation in age at time of upper GI malignancy diagnosis in symptomatic patients referred for upper GI endoscopy. Guideline recommendations for age-based selection should be tailored to local age-related detection rates.https://doi.org/10.1177/1756284820959225 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Judith J. de Jong Marten A. Lantinga Ina M. E. Thijs Philip R. de Reuver Joost P. H. Drenth |
spellingShingle |
Judith J. de Jong Marten A. Lantinga Ina M. E. Thijs Philip R. de Reuver Joost P. H. Drenth Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy Therapeutic Advances in Gastroenterology |
author_facet |
Judith J. de Jong Marten A. Lantinga Ina M. E. Thijs Philip R. de Reuver Joost P. H. Drenth |
author_sort |
Judith J. de Jong |
title |
Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
title_short |
Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
title_full |
Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
title_fullStr |
Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
title_full_unstemmed |
Systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
title_sort |
systematic review with meta-analysis: age-related malignancy detection rates at upper gastrointestinal endoscopy |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Gastroenterology |
issn |
1756-2848 |
publishDate |
2020-11-01 |
description |
Background: Age is an important and objective risk factor for upper gastrointestinal (GI) malignancy. The accuracy of various age limits to detect upper GI malignancy is unclear. Determination of this accuracy may aid in the decision to refer symptomatic patients for upper GI endoscopy. The aim of this analysis was to synthesize data on upper GI malignancy detection rates for various age limits worldwide through meta-analysis. Methods: We searched MEDLINE, EMBASE, and Web of Science in November 2018. Selection criteria included studies addressing malignant findings at upper GI endoscopy in a symptomatic population reporting age at time of diagnosis. Meta-analyses were conducted to derive continent-specific cancer detection rates. Results: A total of 33 studies including 346,641 patients across 21 countries fulfilled the inclusion criteria. To detect >80% of malignant cases all symptomatic patients over 40 years of age should be investigated in Africa, over 50 years of age in South America and Asia, and over 55 years of age in North America and Europe. Conclusion: This systematic review and meta-analysis provides data on intercontinental variation in age at time of upper GI malignancy diagnosis in symptomatic patients referred for upper GI endoscopy. Guideline recommendations for age-based selection should be tailored to local age-related detection rates. |
url |
https://doi.org/10.1177/1756284820959225 |
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