Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure
Background:. Traditionally, nonmelanoma skin cancers (NMSCs) are considered mainly UV-related malignancies. Nevertheless, a strong correlation between the embryologically relevant sites (ERS) of the head and neck and the preferential sites of onset of basal cell carcinomas (BCCs) has long been suppo...
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doaj-a85a82d2c63c4303825874cedd7d18c32020-11-25T03:01:29ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742020-04-0184e268310.1097/GOX.0000000000002683202004000-00019Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV ExposureGiovanni Nicoletti, MD, FEBoPRAS0Marco Mario Tresoldi, MD1Alberto Malovini, MS, PhD2Borelli Francesco, MD3Angela Faga, MD, FICS4From the * Plastic and Reconstructive Surgery, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyFrom the * Plastic and Reconstructive Surgery, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy§ Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri Research and Care Institute, Pavia, Italy¶ Plastic, Reconstructive and Aesthetic Surgery Residency Program, Universities of Milan-Pavia, Pavia, Italy.† Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Center, University of Pavia, Pavia, ItalyBackground:. Traditionally, nonmelanoma skin cancers (NMSCs) are considered mainly UV-related malignancies. Nevertheless, a strong correlation between the embryologically relevant sites (ERS) of the head and neck and the preferential sites of onset of basal cell carcinomas (BCCs) has long been supposed and demonstrated. The aim of this research was the investigation of the potential correlation between the ERS of the head and neck and the sites of tumor onset in all of the NMSCs. Methods:. The distribution of 1165 NMSC was correlated with the ERS of the head and neck using the universally accepted anatomical diagrams featuring the congenital head and neck clefts and an original anatomical diagram showing the most credited sites of the embryonic fusion planes of the auricle. Results:. In our sample, both BCC and SSC display an increased likelihood of onset in the ERS of the head and neck. A proportion of 93.10% BCCs was distributed within ERS, while 6.90% derived from non-embryologically relevant sites (P < 0.001). A proportion of 69.70% SCCs was distributed within ERS, while 30.30% derived from non-embryologically relevant sites (P < 0.001). The probability of tumors within ERS was significantly higher for BCC versus SCC (P < 0.001), with BCCs having a 5-fold increase in the probability of occurring in ERS compared to SCCs (P < 0.001). Conclusions:. The ERS might host areas of cellular instability yielding to the development of an NMSC. The environmental UV exposure plays a relatively main role versus dysontogenic factors in the pathogenesis of SCC.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002683 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Nicoletti, MD, FEBoPRAS Marco Mario Tresoldi, MD Alberto Malovini, MS, PhD Borelli Francesco, MD Angela Faga, MD, FICS |
spellingShingle |
Giovanni Nicoletti, MD, FEBoPRAS Marco Mario Tresoldi, MD Alberto Malovini, MS, PhD Borelli Francesco, MD Angela Faga, MD, FICS Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure Plastic and Reconstructive Surgery, Global Open |
author_facet |
Giovanni Nicoletti, MD, FEBoPRAS Marco Mario Tresoldi, MD Alberto Malovini, MS, PhD Borelli Francesco, MD Angela Faga, MD, FICS |
author_sort |
Giovanni Nicoletti, MD, FEBoPRAS |
title |
Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure |
title_short |
Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure |
title_full |
Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure |
title_fullStr |
Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure |
title_full_unstemmed |
Nonmelanoma Skin Cancers: Embryologically Relevant Sites and UV Exposure |
title_sort |
nonmelanoma skin cancers: embryologically relevant sites and uv exposure |
publisher |
Wolters Kluwer |
series |
Plastic and Reconstructive Surgery, Global Open |
issn |
2169-7574 |
publishDate |
2020-04-01 |
description |
Background:. Traditionally, nonmelanoma skin cancers (NMSCs) are considered mainly UV-related malignancies. Nevertheless, a strong correlation between the embryologically relevant sites (ERS) of the head and neck and the preferential sites of onset of basal cell carcinomas (BCCs) has long been supposed and demonstrated. The aim of this research was the investigation of the potential correlation between the ERS of the head and neck and the sites of tumor onset in all of the NMSCs.
Methods:. The distribution of 1165 NMSC was correlated with the ERS of the head and neck using the universally accepted anatomical diagrams featuring the congenital head and neck clefts and an original anatomical diagram showing the most credited sites of the embryonic fusion planes of the auricle.
Results:. In our sample, both BCC and SSC display an increased likelihood of onset in the ERS of the head and neck. A proportion of 93.10% BCCs was distributed within ERS, while 6.90% derived from non-embryologically relevant sites (P < 0.001). A proportion of 69.70% SCCs was distributed within ERS, while 30.30% derived from non-embryologically relevant sites (P < 0.001). The probability of tumors within ERS was significantly higher for BCC versus SCC (P < 0.001), with BCCs having a 5-fold increase in the probability of occurring in ERS compared to SCCs (P < 0.001).
Conclusions:. The ERS might host areas of cellular instability yielding to the development of an NMSC. The environmental UV exposure plays a relatively main role versus dysontogenic factors in the pathogenesis of SCC. |
url |
http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002683 |
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