Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer
Signet ring cell carcinoma (SRCC) was previously thought to have a worse prognosis than differentiated gastric carcinoma (DC). However, recent studies have shown that its prognosis is related to staging. Here, we analyzed the clinicopathological features and the rate of lymph node metastasis (LNM) i...
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doaj-a85d4e321fff4d43bac798f0e86c23a32021-07-09T09:21:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.630675630675Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric CancerXiaoliang Jin0Wei Wu1Jing Zhao2Shuang Song3Chunli Zhang4Wenyong Sun5Bin Lv6Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pathology, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pathology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pathology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pathology, Zhejiang Cancer Hospital, Hangzhou, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaSignet ring cell carcinoma (SRCC) was previously thought to have a worse prognosis than differentiated gastric carcinoma (DC). However, recent studies have shown that its prognosis is related to staging. Here, we analyzed the clinicopathological features and the rate of lymph node metastasis (LNM) in 2166 patients with gastric cancer (605 early and 1561 advanced cases) who underwent gastrectomy and lymph node dissection (D2) from 2016 to 2019. The LNM rate for early and advanced cases was 18.0% and 74.2%, respectively. Regarding early cases, the LNM rate in SRCC was similar to that in DC (10% vs. 16.1%, p=0.224), and significantly lower than that in undifferentiated carcinoma (UDC; 10% vs. 23.3%, p=0.024). Tumor size, infiltration depth, pathological type, and mixed type were risk factors for LNM in early cases. Regarding intramucosal cases, the LNM rate in SRCC was similar to that in DC (4.3% vs. 3.7%, p=0.852), and significantly lower than that in UDC (11.2%). The LNM rate was significantly higher in submucosal than intramucosal cases (28.1% vs. 6.3%, p<0.001), and in early mixed cases than early pure cases (23.2% vs. 12.4%, p<0.001). Regarding early pure cases, the LNM rate in SRCC was similar to that in DC (9.3% vs. 7.2%, p=0.641), but significantly lower than that in UDC (9.3% vs. 24.7%, p=0.039). In summary, the LNM rate in early SRCC was similar to that in early DC but significantly lower than that in early UDC. Early SRCC fits with the endoscopic submucosal dissection (ESD) indication related to undifferentiated cases, and ESD may be effective. Additionally, the LNM rate was markedly higher for submucosal cases than intramucosal cases, and for mixed cases than pure cases.https://www.frontiersin.org/articles/10.3389/fonc.2021.630675/fullearly gastric cancersignet ring cell carcinomalymph node metastasisclinical featuresendoscopic submucosal dissection (ESD) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoliang Jin Wei Wu Jing Zhao Shuang Song Chunli Zhang Wenyong Sun Bin Lv |
spellingShingle |
Xiaoliang Jin Wei Wu Jing Zhao Shuang Song Chunli Zhang Wenyong Sun Bin Lv Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer Frontiers in Oncology early gastric cancer signet ring cell carcinoma lymph node metastasis clinical features endoscopic submucosal dissection (ESD) |
author_facet |
Xiaoliang Jin Wei Wu Jing Zhao Shuang Song Chunli Zhang Wenyong Sun Bin Lv |
author_sort |
Xiaoliang Jin |
title |
Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer |
title_short |
Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer |
title_full |
Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer |
title_fullStr |
Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer |
title_full_unstemmed |
Clinical Features and Risk Factors for Lymph Node Metastasis in Early Signet Ring Cell Gastric Cancer |
title_sort |
clinical features and risk factors for lymph node metastasis in early signet ring cell gastric cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-07-01 |
description |
Signet ring cell carcinoma (SRCC) was previously thought to have a worse prognosis than differentiated gastric carcinoma (DC). However, recent studies have shown that its prognosis is related to staging. Here, we analyzed the clinicopathological features and the rate of lymph node metastasis (LNM) in 2166 patients with gastric cancer (605 early and 1561 advanced cases) who underwent gastrectomy and lymph node dissection (D2) from 2016 to 2019. The LNM rate for early and advanced cases was 18.0% and 74.2%, respectively. Regarding early cases, the LNM rate in SRCC was similar to that in DC (10% vs. 16.1%, p=0.224), and significantly lower than that in undifferentiated carcinoma (UDC; 10% vs. 23.3%, p=0.024). Tumor size, infiltration depth, pathological type, and mixed type were risk factors for LNM in early cases. Regarding intramucosal cases, the LNM rate in SRCC was similar to that in DC (4.3% vs. 3.7%, p=0.852), and significantly lower than that in UDC (11.2%). The LNM rate was significantly higher in submucosal than intramucosal cases (28.1% vs. 6.3%, p<0.001), and in early mixed cases than early pure cases (23.2% vs. 12.4%, p<0.001). Regarding early pure cases, the LNM rate in SRCC was similar to that in DC (9.3% vs. 7.2%, p=0.641), but significantly lower than that in UDC (9.3% vs. 24.7%, p=0.039). In summary, the LNM rate in early SRCC was similar to that in early DC but significantly lower than that in early UDC. Early SRCC fits with the endoscopic submucosal dissection (ESD) indication related to undifferentiated cases, and ESD may be effective. Additionally, the LNM rate was markedly higher for submucosal cases than intramucosal cases, and for mixed cases than pure cases. |
topic |
early gastric cancer signet ring cell carcinoma lymph node metastasis clinical features endoscopic submucosal dissection (ESD) |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.630675/full |
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