Correlation between Iron Status and Simple Febrile Seizures in Children
Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile sei...
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2021-07-01
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doaj-a861a06ce54c435c9ec35dbcc7a30c432021-08-06T18:57:23ZengEgyptian knowledge bankInternational Journal of Medical Arts2636-41742682-37802021-07-01331714171810.21608/ijma.2021.79064.1320186029Correlation between Iron Status and Simple Febrile Seizures in ChildrenMarwa Elkafafy0Magdy Sakr1Mohamed Elsamanoudy2hesham abd al-samee3Department of Pediatrics, EL-Raml Pediatric Hospital, Ministry of Health, EgyptDepartment of Pediatrics, Damietta Faculty of Medicine, AL-Azhar University, EgyptDepartment of Pediatrics, Damietta Faculty of Medicine, AL-Azhar University, EgyptDepartment of Clinical Pathology, Damietta Faculty of Medicine, AL-Azhar University, EgyptBackground: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile seizures. Objective: To study iron status among children with simple febrile seizures, and to estimate the prevalence of iron deficiency between them. Patients and methods: A case-control study included 100 febrile children aged 6 months to 60 months, and were ascribed to 2 groups; 50 children with simple febrile seizures [case group], and 50 children who had febrile disease without occurrence of seizures [control group]. Venous samples were obtained for the analysis of complete blood count, and iron indices [serum ferritin, serum iron and total iron binding capacity]. Results: The peak temperature was significantly elevated among the case group [P=0.03]. Regarding iron profile, compared to controls, the case group had significantly lower iron [54.24±16.04 vs. 62.6±16.02; P=0.011], and lower ferritin [37.612±19.85 vs. 80.624±31.57; P <0.001]. Correlation analysis revealed a significant negative correlation between serum ferritin and frequency of febrile seizures [P=0.025] Conclusions: Iron deficiency and iron deficiency anemia were more common among children with simple febrile seizures, and they were associated with increase in the duration and frequency of seizures. Special attention should be paid for the assessment of iron status among children with febrile seizures.https://ijma.journals.ekb.eg/article_186029_8a360b69fef9dd38bef8343c39f6a359.pdffeverseizuresironanemiafebrile seizures |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee |
spellingShingle |
Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee Correlation between Iron Status and Simple Febrile Seizures in Children International Journal of Medical Arts fever seizures iron anemia febrile seizures |
author_facet |
Marwa Elkafafy Magdy Sakr Mohamed Elsamanoudy hesham abd al-samee |
author_sort |
Marwa Elkafafy |
title |
Correlation between Iron Status and Simple Febrile Seizures in Children |
title_short |
Correlation between Iron Status and Simple Febrile Seizures in Children |
title_full |
Correlation between Iron Status and Simple Febrile Seizures in Children |
title_fullStr |
Correlation between Iron Status and Simple Febrile Seizures in Children |
title_full_unstemmed |
Correlation between Iron Status and Simple Febrile Seizures in Children |
title_sort |
correlation between iron status and simple febrile seizures in children |
publisher |
Egyptian knowledge bank |
series |
International Journal of Medical Arts |
issn |
2636-4174 2682-3780 |
publishDate |
2021-07-01 |
description |
Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile seizures. Objective: To study iron status among children with simple febrile seizures, and to estimate the prevalence of iron deficiency between them. Patients and methods: A case-control study included 100 febrile children aged 6 months to 60 months, and were ascribed to 2 groups; 50 children with simple febrile seizures [case group], and 50 children who had febrile disease without occurrence of seizures [control group]. Venous samples were obtained for the analysis of complete blood count, and iron indices [serum ferritin, serum iron and total iron binding capacity]. Results: The peak temperature was significantly elevated among the case group [P=0.03]. Regarding iron profile, compared to controls, the case group had significantly lower iron [54.24±16.04 vs. 62.6±16.02; P=0.011], and lower ferritin [37.612±19.85 vs. 80.624±31.57; P <0.001]. Correlation analysis revealed a significant negative correlation between serum ferritin and frequency of febrile seizures [P=0.025] Conclusions: Iron deficiency and iron deficiency anemia were more common among children with simple febrile seizures, and they were associated with increase in the duration and frequency of seizures. Special attention should be paid for the assessment of iron status among children with febrile seizures. |
topic |
fever seizures iron anemia febrile seizures |
url |
https://ijma.journals.ekb.eg/article_186029_8a360b69fef9dd38bef8343c39f6a359.pdf |
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