Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents.
Changing sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous stud...
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doaj-a86c043090d9432f80936df463d83bfa2021-07-04T04:30:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024372010.1371/journal.pone.0243720Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents.Winok LapidaireAnna S UrrilaEric ArtigesRuben MirandaHélène VulserPauline Bézivin-FrereHervé LemaîtreJani PenttiläTobias BanaschewskiArun L W BokdeUli BrombergChristian BüchelPatricia J ConrodSylvane DesrivièresVincent FrouinJürgen GallinatHugh GaravanPenny GowlandAndreas HeinzBernd IttermannDimitri Papadopoulos-OrfanosTomáš PausMichael N SmolkaGunter SchumannMarie-Laure Paillère MartinotJean-Luc MartinotIMAGEN consortiumChanging sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n = 101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationships between sleep habits, assessed with self-reports, and regional grey matter volumes, and psychological functioning, assessed with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and externalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development.https://doi.org/10.1371/journal.pone.0243720 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Winok Lapidaire Anna S Urrila Eric Artiges Ruben Miranda Hélène Vulser Pauline Bézivin-Frere Hervé Lemaître Jani Penttilä Tobias Banaschewski Arun L W Bokde Uli Bromberg Christian Büchel Patricia J Conrod Sylvane Desrivières Vincent Frouin Jürgen Gallinat Hugh Garavan Penny Gowland Andreas Heinz Bernd Ittermann Dimitri Papadopoulos-Orfanos Tomáš Paus Michael N Smolka Gunter Schumann Marie-Laure Paillère Martinot Jean-Luc Martinot IMAGEN consortium |
spellingShingle |
Winok Lapidaire Anna S Urrila Eric Artiges Ruben Miranda Hélène Vulser Pauline Bézivin-Frere Hervé Lemaître Jani Penttilä Tobias Banaschewski Arun L W Bokde Uli Bromberg Christian Büchel Patricia J Conrod Sylvane Desrivières Vincent Frouin Jürgen Gallinat Hugh Garavan Penny Gowland Andreas Heinz Bernd Ittermann Dimitri Papadopoulos-Orfanos Tomáš Paus Michael N Smolka Gunter Schumann Marie-Laure Paillère Martinot Jean-Luc Martinot IMAGEN consortium Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. PLoS ONE |
author_facet |
Winok Lapidaire Anna S Urrila Eric Artiges Ruben Miranda Hélène Vulser Pauline Bézivin-Frere Hervé Lemaître Jani Penttilä Tobias Banaschewski Arun L W Bokde Uli Bromberg Christian Büchel Patricia J Conrod Sylvane Desrivières Vincent Frouin Jürgen Gallinat Hugh Garavan Penny Gowland Andreas Heinz Bernd Ittermann Dimitri Papadopoulos-Orfanos Tomáš Paus Michael N Smolka Gunter Schumann Marie-Laure Paillère Martinot Jean-Luc Martinot IMAGEN consortium |
author_sort |
Winok Lapidaire |
title |
Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
title_short |
Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
title_full |
Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
title_fullStr |
Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
title_full_unstemmed |
Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
title_sort |
irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
Changing sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n = 101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationships between sleep habits, assessed with self-reports, and regional grey matter volumes, and psychological functioning, assessed with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and externalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development. |
url |
https://doi.org/10.1371/journal.pone.0243720 |
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