Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma
Metastatic renal cell carcinoma with sarcomatoid histology (SmRCC) is associated with poor survival. No data is available from randomized trials on the efficacy of vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors in SmRCC. We identified SmRCC patients fro...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Journal of Oncology |
Online Access: | http://dx.doi.org/10.1155/2015/181926 |
id |
doaj-a87798892de4467db7e2b10b89990329 |
---|---|
record_format |
Article |
spelling |
doaj-a87798892de4467db7e2b10b899903292020-11-24T23:13:06ZengHindawi LimitedJournal of Oncology1687-84501687-84692015-01-01201510.1155/2015/181926181926Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell CarcinomaSrinivas K. Tantravahi0Daniel Albertson1Archana M. Agarwal2Sowmya Ravulapati3Austin Poole4Shiven B. Patel5Jamil S. Hawatmeh6Alli M. Straubhar7Ting Liu8David D. Stenehjem9Neeraj Agarwal10Department of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USAARUP Laboratories, Department of Pathology, The University of Utah, Salt Lake City, UT 84108, USAARUP Laboratories, Department of Pathology, The University of Utah, Salt Lake City, UT 84108, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USAARUP Laboratories, Department of Pathology, The University of Utah, Salt Lake City, UT 84108, USAPharmacotherapy Outcomes Research Center (PORC), College of Pharmacy, The University of Utah, Salt Lake City, UT 84112, USADepartment of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, USAMetastatic renal cell carcinoma with sarcomatoid histology (SmRCC) is associated with poor survival. No data is available from randomized trials on the efficacy of vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors in SmRCC. We identified SmRCC patients from a single institutional database. To identify predictive and prognostic biomarkers, immunohistochemistry (IHC) analysis was performed on the tumor samples for downstream targets of VEGF and mTOR pathways. Survival outcomes were stratified by IHC analysis, extent of sarcomatoid component, Memorial Sloan-Kettering Cancer Center (MSKCC), and Heng risk criteria. Twenty-seven patients with SmRCC were included. First line therapy included targeted therapy (n=19), immunotherapy (n=4), cytotoxic chemotherapy (n=1), and no treatment (n=3). Median OS was 8.2 months (95% CI 3.8–14.2 months). Median survival in months, based on MSKCC and Heng risk groups, was favorable 89.3 versus 84.5, intermediate 9.5 versus 12.7, and poor 3.9 versus 5.1. None of the IHC markers predicted outcomes of treatment with VEGF or mTOR inhibitors. Only tumor IMP3 expression was associated with inferior OS, although not statistically significant (IMP3 negative 14.2 versus IMP3 positive 4.9 months; HR 0.46, 95% CI 0.16–1.21; P=0.12). The study was limited by small sample size.http://dx.doi.org/10.1155/2015/181926 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Srinivas K. Tantravahi Daniel Albertson Archana M. Agarwal Sowmya Ravulapati Austin Poole Shiven B. Patel Jamil S. Hawatmeh Alli M. Straubhar Ting Liu David D. Stenehjem Neeraj Agarwal |
spellingShingle |
Srinivas K. Tantravahi Daniel Albertson Archana M. Agarwal Sowmya Ravulapati Austin Poole Shiven B. Patel Jamil S. Hawatmeh Alli M. Straubhar Ting Liu David D. Stenehjem Neeraj Agarwal Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma Journal of Oncology |
author_facet |
Srinivas K. Tantravahi Daniel Albertson Archana M. Agarwal Sowmya Ravulapati Austin Poole Shiven B. Patel Jamil S. Hawatmeh Alli M. Straubhar Ting Liu David D. Stenehjem Neeraj Agarwal |
author_sort |
Srinivas K. Tantravahi |
title |
Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma |
title_short |
Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma |
title_full |
Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma |
title_fullStr |
Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma |
title_full_unstemmed |
Survival Outcomes and Tumor IMP3 Expression in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma |
title_sort |
survival outcomes and tumor imp3 expression in patients with sarcomatoid metastatic renal cell carcinoma |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2015-01-01 |
description |
Metastatic renal cell carcinoma with sarcomatoid histology (SmRCC) is associated with poor survival. No data is available from randomized trials on the efficacy of vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors in SmRCC. We identified SmRCC patients from a single institutional database. To identify predictive and prognostic biomarkers, immunohistochemistry (IHC) analysis was performed on the tumor samples for downstream targets of VEGF and mTOR pathways. Survival outcomes were stratified by IHC analysis, extent of sarcomatoid component, Memorial Sloan-Kettering Cancer Center (MSKCC), and Heng risk criteria. Twenty-seven patients with SmRCC were included. First line therapy included targeted therapy (n=19), immunotherapy (n=4), cytotoxic chemotherapy (n=1), and no treatment (n=3). Median OS was 8.2 months (95% CI 3.8–14.2 months). Median survival in months, based on MSKCC and Heng risk groups, was favorable 89.3 versus 84.5, intermediate 9.5 versus 12.7, and poor 3.9 versus 5.1. None of the IHC markers predicted outcomes of treatment with VEGF or mTOR inhibitors. Only tumor IMP3 expression was associated with inferior OS, although not statistically significant (IMP3 negative 14.2 versus IMP3 positive 4.9 months; HR 0.46, 95% CI 0.16–1.21; P=0.12). The study was limited by small sample size. |
url |
http://dx.doi.org/10.1155/2015/181926 |
work_keys_str_mv |
AT srinivasktantravahi survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT danielalbertson survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT archanamagarwal survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT sowmyaravulapati survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT austinpoole survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT shivenbpatel survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT jamilshawatmeh survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT allimstraubhar survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT tingliu survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT daviddstenehjem survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma AT neerajagarwal survivaloutcomesandtumorimp3expressioninpatientswithsarcomatoidmetastaticrenalcellcarcinoma |
_version_ |
1725599350838525952 |