Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film

• Main Authors: Xiaoning Zhang, Zhenyu Chen, Hong Bao, Jianwei Liang, Shui Xu, Guotao Cheng, Yong Zhu
• Format: Article
• Language: English
• Published: MDPI AG 2019-10-01
• Series: Materials
• Subjects: silk fibroin; curcumin; sustained-release; antibacterial activity; cytotoxicity
• Online Access: https://www.mdpi.com/1996-1944/12/20/3340

In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it was found that the prepared SF/Gly/GA/Cur film possessed the capability to effectively inhibit the growth of bacteria and prevent bacterial penetration with a suitable water vapor transmission rate. Furthermore, the prepared composite film was non-cytotoxic, which makes it an ideal material for wound dressings.