Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expre...
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doaj-a87b478e712241bea2ed83394a4bc3fb2021-04-22T23:00:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01224358435810.3390/ijms22094358Fibrinolytic System and Cancer: Diagnostic and Therapeutic ApplicationsNiaz Mahmood0Shafaat A. Rabbani1Department of Medicine, McGill University, Montréal, QC H4A3J1, CanadaDepartment of Medicine, McGill University, Montréal, QC H4A3J1, CanadaFibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expression of several components, especially urokinase-type plasminogen activator (uPA), its cognate receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), has shown a direct correlation with increased tumor growth, invasiveness, and metastasis. As a result, targeting the fibrinolytic system has been of great interest in the field of cancer biology. Even though there is a plethora of encouraging preclinical evidence on the potential therapeutic benefits of targeting the key oncogenic components of the fibrinolytic system, none of them made it from “bench to bedside” due to a limited number of clinical trials on them. This review summarizes our existing understanding of the various diagnostic and therapeutic strategies targeting the fibrinolytic system during cancer.https://www.mdpi.com/1422-0067/22/9/4358uPAuPARPAI-1PA systemcancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Niaz Mahmood Shafaat A. Rabbani |
spellingShingle |
Niaz Mahmood Shafaat A. Rabbani Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications International Journal of Molecular Sciences uPA uPAR PAI-1 PA system cancer |
author_facet |
Niaz Mahmood Shafaat A. Rabbani |
author_sort |
Niaz Mahmood |
title |
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications |
title_short |
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications |
title_full |
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications |
title_fullStr |
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications |
title_full_unstemmed |
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications |
title_sort |
fibrinolytic system and cancer: diagnostic and therapeutic applications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-04-01 |
description |
Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by counteracting excessive thrombosis. The components of the fibrinolytic system are well established and are associated with a wide array of physiological and pathophysiological processes. The aberrant expression of several components, especially urokinase-type plasminogen activator (uPA), its cognate receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), has shown a direct correlation with increased tumor growth, invasiveness, and metastasis. As a result, targeting the fibrinolytic system has been of great interest in the field of cancer biology. Even though there is a plethora of encouraging preclinical evidence on the potential therapeutic benefits of targeting the key oncogenic components of the fibrinolytic system, none of them made it from “bench to bedside” due to a limited number of clinical trials on them. This review summarizes our existing understanding of the various diagnostic and therapeutic strategies targeting the fibrinolytic system during cancer. |
topic |
uPA uPAR PAI-1 PA system cancer |
url |
https://www.mdpi.com/1422-0067/22/9/4358 |
work_keys_str_mv |
AT niazmahmood fibrinolyticsystemandcancerdiagnosticandtherapeuticapplications AT shafaatarabbani fibrinolyticsystemandcancerdiagnosticandtherapeuticapplications |
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1721514051266150400 |