Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
Introduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One h...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Behavioural Neurology |
Online Access: | http://dx.doi.org/10.1155/2015/976589 |
id |
doaj-a87c2632b7ec4d88a64512fafa7d4862 |
---|---|
record_format |
Article |
spelling |
doaj-a87c2632b7ec4d88a64512fafa7d48622021-07-02T02:28:50ZengHindawi LimitedBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/976589976589Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease ProgressionSara Cavaco0Alexandra Gonçalves1Alexandre Mendes2Nuno Vila-Chã3Inês Moreira4Joana Fernandes5Joana Damásio6Armando Teixeira-Pinto7António Bastos Lima8Serviço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalUnidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050 Porto, PortugalUnidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalCINTESIS, Faculdade de Medicina, Universidade do Porto, 4200 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalIntroduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson’s Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression.http://dx.doi.org/10.1155/2015/976589 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Cavaco Alexandra Gonçalves Alexandre Mendes Nuno Vila-Chã Inês Moreira Joana Fernandes Joana Damásio Armando Teixeira-Pinto António Bastos Lima |
spellingShingle |
Sara Cavaco Alexandra Gonçalves Alexandre Mendes Nuno Vila-Chã Inês Moreira Joana Fernandes Joana Damásio Armando Teixeira-Pinto António Bastos Lima Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression Behavioural Neurology |
author_facet |
Sara Cavaco Alexandra Gonçalves Alexandre Mendes Nuno Vila-Chã Inês Moreira Joana Fernandes Joana Damásio Armando Teixeira-Pinto António Bastos Lima |
author_sort |
Sara Cavaco |
title |
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression |
title_short |
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression |
title_full |
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression |
title_fullStr |
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression |
title_full_unstemmed |
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression |
title_sort |
abnormal olfaction in parkinson’s disease is related to faster disease progression |
publisher |
Hindawi Limited |
series |
Behavioural Neurology |
issn |
0953-4180 1875-8584 |
publishDate |
2015-01-01 |
description |
Introduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson’s Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression. |
url |
http://dx.doi.org/10.1155/2015/976589 |
work_keys_str_mv |
AT saracavaco abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT alexandragoncalves abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT alexandremendes abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT nunovilacha abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT inesmoreira abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT joanafernandes abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT joanadamasio abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT armandoteixeirapinto abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression AT antoniobastoslima abnormalolfactioninparkinsonsdiseaseisrelatedtofasterdiseaseprogression |
_version_ |
1721343284011335680 |