Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression

Introduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One h...

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Main Authors: Sara Cavaco, Alexandra Gonçalves, Alexandre Mendes, Nuno Vila-Chã, Inês Moreira, Joana Fernandes, Joana Damásio, Armando Teixeira-Pinto, António Bastos Lima
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2015/976589
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spelling doaj-a87c2632b7ec4d88a64512fafa7d48622021-07-02T02:28:50ZengHindawi LimitedBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/976589976589Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease ProgressionSara Cavaco0Alexandra Gonçalves1Alexandre Mendes2Nuno Vila-Chã3Inês Moreira4Joana Fernandes5Joana Damásio6Armando Teixeira-Pinto7António Bastos Lima8Serviço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalUnidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050 Porto, PortugalUnidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalCINTESIS, Faculdade de Medicina, Universidade do Porto, 4200 Porto, PortugalServiço de Neurologia, Centro Hospitalar do Porto, 4099 Porto, PortugalIntroduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson’s Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression.http://dx.doi.org/10.1155/2015/976589
collection DOAJ
language English
format Article
sources DOAJ
author Sara Cavaco
Alexandra Gonçalves
Alexandre Mendes
Nuno Vila-Chã
Inês Moreira
Joana Fernandes
Joana Damásio
Armando Teixeira-Pinto
António Bastos Lima
spellingShingle Sara Cavaco
Alexandra Gonçalves
Alexandre Mendes
Nuno Vila-Chã
Inês Moreira
Joana Fernandes
Joana Damásio
Armando Teixeira-Pinto
António Bastos Lima
Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
Behavioural Neurology
author_facet Sara Cavaco
Alexandra Gonçalves
Alexandre Mendes
Nuno Vila-Chã
Inês Moreira
Joana Fernandes
Joana Damásio
Armando Teixeira-Pinto
António Bastos Lima
author_sort Sara Cavaco
title Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
title_short Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
title_full Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
title_fullStr Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
title_full_unstemmed Abnormal Olfaction in Parkinson’s Disease Is Related to Faster Disease Progression
title_sort abnormal olfaction in parkinson’s disease is related to faster disease progression
publisher Hindawi Limited
series Behavioural Neurology
issn 0953-4180
1875-8584
publishDate 2015-01-01
description Introduction. A possible association between olfactory dysfunction and Parkinson’s disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation. Methods. One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12 h without antiparkinsonian medication. Results. Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson’s Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account. Conclusions. Abnormal olfaction in PD is associated with increased severity and faster disease progression.
url http://dx.doi.org/10.1155/2015/976589
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