Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contrib...
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doaj-a87f36a41d8e48a4bdb32f5f5770f0f72020-11-24T23:15:13ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-03-01910.3389/fmicb.2018.00432329141Intestinal Microbiota Influences Non-intestinal Related Autoimmune DiseasesMaria C. Opazo0Maria C. Opazo1Elizabeth M. Ortega-Rocha2Irenice Coronado-Arrázola3Laura C. Bonifaz4Helene Boudin5Michel Neunlist6Susan M. Bueno7Alexis M. Kalergis8Alexis M. Kalergis9Claudia A. Riedel10Claudia A. Riedel11Laboratorio de Biología Celular y Farmacología, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, ChileFacultad de Medicina, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, ChileLaboratorio de Inmunobiología, Facultad de Medicina, Departamento de Biología Celular y Tisular, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileUnidad de Investigación Médica en Inmunoquímica Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, MexicoInstitut National de la Santé et de la Recherche Médicale U1235, Institut des Maladies de l'Appareil Digestif, Université de Nantes, Nantes, FranceInstitut National de la Santé et de la Recherche Médicale U1235, Institut des Maladies de l'Appareil Digestif, Université de Nantes, Nantes, FranceDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Endocrinología, Facultad de Medicina, Pontificia Universidad, Metropolitana, ChileLaboratorio de Biología Celular y Farmacología, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, ChileFacultad de Medicina, Millennium Institute on Immunology and Immunotherapy, Universidad Andres Bello, Santiago, ChileThe human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases.http://journal.frontiersin.org/article/10.3389/fmicb.2018.00432/fullmicrobiotaautoimmune diseasegutmicrobiomeskinCNS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria C. Opazo Maria C. Opazo Elizabeth M. Ortega-Rocha Irenice Coronado-Arrázola Laura C. Bonifaz Helene Boudin Michel Neunlist Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis Claudia A. Riedel Claudia A. Riedel |
spellingShingle |
Maria C. Opazo Maria C. Opazo Elizabeth M. Ortega-Rocha Irenice Coronado-Arrázola Laura C. Bonifaz Helene Boudin Michel Neunlist Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis Claudia A. Riedel Claudia A. Riedel Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases Frontiers in Microbiology microbiota autoimmune disease gut microbiome skin CNS |
author_facet |
Maria C. Opazo Maria C. Opazo Elizabeth M. Ortega-Rocha Irenice Coronado-Arrázola Laura C. Bonifaz Helene Boudin Michel Neunlist Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis Claudia A. Riedel Claudia A. Riedel |
author_sort |
Maria C. Opazo |
title |
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases |
title_short |
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases |
title_full |
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases |
title_fullStr |
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases |
title_full_unstemmed |
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases |
title_sort |
intestinal microbiota influences non-intestinal related autoimmune diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2018-03-01 |
description |
The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases. |
topic |
microbiota autoimmune disease gut microbiome skin CNS |
url |
http://journal.frontiersin.org/article/10.3389/fmicb.2018.00432/full |
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