Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.
BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein induces mitochondrial dysfunction, often leading to cell death. However, some highly respiring cells and cancer cells tolerate BNIP3 expression,...
Main Authors: | Katherine E Liu, William A Frazier |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4477977?pdf=render |
Similar Items
-
The Role of Bnip3 and autophagy in chemodrug induced cell death of cancer cell
by: Kai-Chi Yang, et al.
Published: (2012) -
Autophagy and BNIP3 protein in tumorogenesis
by: Ewelina Świderek, et al.
Published: (2013-05-01) -
Tyrosine Phosphorylated BNIP3 Decreases Nitric Oxide-induced Cell Death in Nerve Cells
by: Lih-Rou Rau, et al.
Published: (2011) -
The regulation of phosphorylation at the C-terminus of p53
by: McKendrick, Linda
Published: (1996) -
p53 mediates autophagy and cell death by a mechanism contingent upon Bnip3
by: Wang, Yan
Published: (2013)