Thalassemias in South Asia: clinical lessons learnt from Bangladesh
Abstract Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite...
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doaj-a8a569c5a03c408daa6c98a4c2f50db32020-11-25T00:47:06ZengBMCOrphanet Journal of Rare Diseases1750-11722017-05-011211910.1186/s13023-017-0643-zThalassemias in South Asia: clinical lessons learnt from BangladeshMohammad Sorowar Hossain0Enayetur Raheem1Tanvira Afroze Sultana2Shameema Ferdous3Nusrat Nahar4Sazia Islam5Mohammad Arifuzzaman6Mohammad Abdur Razzaque7Rabiul Alam8Sonia Aziz9Hazera Khatun10Abdur Rahim11Manzur Morshed12Biomedical Research FoundationBiomedical Research FoundationBiomedical Research FoundationBiomedical Research FoundationThalassemia Foundation HospitalTrinity CollegeBiomedical Research FoundationBiomedical Research FoundationBiomedical Research FoundationDepartment of Economics & Business, Moravian CollegeSaint Michael’s Medical CenterThalassemia Foundation HospitalThalassemia Foundation HospitalAbstract Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite the fact that Bangladesh lies in the world’s thalassemia belt, the information on different aspects (epidemiology, clinical course, mortality, complications and treatment outcomes) of thalassemias is lacking. In this comprehensive review, the aim is to to depict the epidemiological aspects of thalassemias, mutation profile and current treatment and management practices in the country by sharing the experience of dealing with 1178 cases over 2009–2014 time periods in a specialized thalassemia treatment centre. We have also discussed the preventative strategies of thalassemias from the context of Bangladesh which could be effective for other developing countries.http://link.springer.com/article/10.1186/s13023-017-0643-zBeta thalassemiaHemoglobinopathiesThalassemia traitBeta thalassemia majorHbE beta thalassemiaNon-transfusion dependent thalassemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Sorowar Hossain Enayetur Raheem Tanvira Afroze Sultana Shameema Ferdous Nusrat Nahar Sazia Islam Mohammad Arifuzzaman Mohammad Abdur Razzaque Rabiul Alam Sonia Aziz Hazera Khatun Abdur Rahim Manzur Morshed |
spellingShingle |
Mohammad Sorowar Hossain Enayetur Raheem Tanvira Afroze Sultana Shameema Ferdous Nusrat Nahar Sazia Islam Mohammad Arifuzzaman Mohammad Abdur Razzaque Rabiul Alam Sonia Aziz Hazera Khatun Abdur Rahim Manzur Morshed Thalassemias in South Asia: clinical lessons learnt from Bangladesh Orphanet Journal of Rare Diseases Beta thalassemia Hemoglobinopathies Thalassemia trait Beta thalassemia major HbE beta thalassemia Non-transfusion dependent thalassemia |
author_facet |
Mohammad Sorowar Hossain Enayetur Raheem Tanvira Afroze Sultana Shameema Ferdous Nusrat Nahar Sazia Islam Mohammad Arifuzzaman Mohammad Abdur Razzaque Rabiul Alam Sonia Aziz Hazera Khatun Abdur Rahim Manzur Morshed |
author_sort |
Mohammad Sorowar Hossain |
title |
Thalassemias in South Asia: clinical lessons learnt from Bangladesh |
title_short |
Thalassemias in South Asia: clinical lessons learnt from Bangladesh |
title_full |
Thalassemias in South Asia: clinical lessons learnt from Bangladesh |
title_fullStr |
Thalassemias in South Asia: clinical lessons learnt from Bangladesh |
title_full_unstemmed |
Thalassemias in South Asia: clinical lessons learnt from Bangladesh |
title_sort |
thalassemias in south asia: clinical lessons learnt from bangladesh |
publisher |
BMC |
series |
Orphanet Journal of Rare Diseases |
issn |
1750-1172 |
publishDate |
2017-05-01 |
description |
Abstract Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the coming decades in South Asia. Despite the fact that Bangladesh lies in the world’s thalassemia belt, the information on different aspects (epidemiology, clinical course, mortality, complications and treatment outcomes) of thalassemias is lacking. In this comprehensive review, the aim is to to depict the epidemiological aspects of thalassemias, mutation profile and current treatment and management practices in the country by sharing the experience of dealing with 1178 cases over 2009–2014 time periods in a specialized thalassemia treatment centre. We have also discussed the preventative strategies of thalassemias from the context of Bangladesh which could be effective for other developing countries. |
topic |
Beta thalassemia Hemoglobinopathies Thalassemia trait Beta thalassemia major HbE beta thalassemia Non-transfusion dependent thalassemia |
url |
http://link.springer.com/article/10.1186/s13023-017-0643-z |
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