Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease
Yiben Huang,1,* Jianing Wang,1,2,* Jiamin Shen,1,2,* Jiedong Ma,1,2 Xiaqi Miao,1,2 Keke Ding,1,2 Bingqian Jiang,1,2 Binbin Hu,1,2 Fangyi Fu,1,2 Lingzhi Huang,1 Meiying Cao,3 Xiaodiao Zhang1 1Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Peo...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2021-03-01
|
Series: | International Journal of COPD |
Subjects: | |
Online Access: | https://www.dovepress.com/relationship-of-red-cell-index-with-the-severity-of-chronic-obstructiv-peer-reviewed-article-COPD |
id |
doaj-a8ae89d8407b44f798cb0072d308175d |
---|---|
record_format |
Article |
spelling |
doaj-a8ae89d8407b44f798cb0072d308175d2021-03-28T19:57:50ZengDove Medical PressInternational Journal of COPD1178-20052021-03-01Volume 1682583463445Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary DiseaseHuang YWang JShen JMa JMiao XDing KJiang BHu BFu FHuang LCao MZhang XYiben Huang,1,* Jianing Wang,1,2,* Jiamin Shen,1,2,* Jiedong Ma,1,2 Xiaqi Miao,1,2 Keke Ding,1,2 Bingqian Jiang,1,2 Binbin Hu,1,2 Fangyi Fu,1,2 Lingzhi Huang,1 Meiying Cao,3 Xiaodiao Zhang1 1Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, People’s Republic of China; 3Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaodiao ZhangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaTel +86-577-65866223Fax +86-577-65866586Email xiaodiao_zhang@126.comMeiying CaoDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University Email 519243591@qq.comBackground: We aimed to investigate the association between red cell index (RCI) and the severity of Chronic Obstructive Pulmonary Disease (COPD), and compare predictive value of RCI, neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) for the severity of COPD.Methods: A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to the optimal cut-off value of RCI determined by the receiver operating characteristic (ROC) curve. Pearson’s correlation test, logistic regression analysis and other tests were performed.Results: Compared with low RCI group, the forced expiration volume in 1 second (FEV1) and FEV1 in percent of the predicted value (FEV1%) in high RCI group were lower (p = 0.016, p = 0.001). There was a negative correlation between RCI and FEV1% (r = − 0.302, p = 0.004), while no correlation between FEV1% and NLR as well as PLR were found. RCI showed higher predictive value than NLR and PLR for predicting Global Initiative for Chronic Obstructive Lung Disease classification (GOLD), with a cut-off value of 1.75 and area under the curve (AUC) of 0.729 (p = 0.001). Multivariate logistic regression analysis proved that RCI was an independent factor for lung function in COPD patients (odds ratio [OR] = 4.27, 95% CI: 1.57– 11.63, p = 0.004).Conclusion: RCI is a novel biomarker that can better assess pulmonary function and severity of COPD than NLR and PLR. Higher RCI is related to deterioration of pulmonary function.Keywords: COPD, pulmonary function, RCI, biomarkerhttps://www.dovepress.com/relationship-of-red-cell-index-with-the-severity-of-chronic-obstructiv-peer-reviewed-article-COPDcopdpulmonary functionrcibiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huang Y Wang J Shen J Ma J Miao X Ding K Jiang B Hu B Fu F Huang L Cao M Zhang X |
spellingShingle |
Huang Y Wang J Shen J Ma J Miao X Ding K Jiang B Hu B Fu F Huang L Cao M Zhang X Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease International Journal of COPD copd pulmonary function rci biomarker |
author_facet |
Huang Y Wang J Shen J Ma J Miao X Ding K Jiang B Hu B Fu F Huang L Cao M Zhang X |
author_sort |
Huang Y |
title |
Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease |
title_short |
Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease |
title_full |
Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease |
title_fullStr |
Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease |
title_full_unstemmed |
Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease |
title_sort |
relationship of red cell index with the severity of chronic obstructive pulmonary disease |
publisher |
Dove Medical Press |
series |
International Journal of COPD |
issn |
1178-2005 |
publishDate |
2021-03-01 |
description |
Yiben Huang,1,* Jianing Wang,1,2,* Jiamin Shen,1,2,* Jiedong Ma,1,2 Xiaqi Miao,1,2 Keke Ding,1,2 Bingqian Jiang,1,2 Binbin Hu,1,2 Fangyi Fu,1,2 Lingzhi Huang,1 Meiying Cao,3 Xiaodiao Zhang1 1Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, People’s Republic of China; 3Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaodiao ZhangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaTel +86-577-65866223Fax +86-577-65866586Email xiaodiao_zhang@126.comMeiying CaoDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University Email 519243591@qq.comBackground: We aimed to investigate the association between red cell index (RCI) and the severity of Chronic Obstructive Pulmonary Disease (COPD), and compare predictive value of RCI, neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) for the severity of COPD.Methods: A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to the optimal cut-off value of RCI determined by the receiver operating characteristic (ROC) curve. Pearson’s correlation test, logistic regression analysis and other tests were performed.Results: Compared with low RCI group, the forced expiration volume in 1 second (FEV1) and FEV1 in percent of the predicted value (FEV1%) in high RCI group were lower (p = 0.016, p = 0.001). There was a negative correlation between RCI and FEV1% (r = − 0.302, p = 0.004), while no correlation between FEV1% and NLR as well as PLR were found. RCI showed higher predictive value than NLR and PLR for predicting Global Initiative for Chronic Obstructive Lung Disease classification (GOLD), with a cut-off value of 1.75 and area under the curve (AUC) of 0.729 (p = 0.001). Multivariate logistic regression analysis proved that RCI was an independent factor for lung function in COPD patients (odds ratio [OR] = 4.27, 95% CI: 1.57– 11.63, p = 0.004).Conclusion: RCI is a novel biomarker that can better assess pulmonary function and severity of COPD than NLR and PLR. Higher RCI is related to deterioration of pulmonary function.Keywords: COPD, pulmonary function, RCI, biomarker |
topic |
copd pulmonary function rci biomarker |
url |
https://www.dovepress.com/relationship-of-red-cell-index-with-the-severity-of-chronic-obstructiv-peer-reviewed-article-COPD |
work_keys_str_mv |
AT huangy relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT wangj relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT shenj relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT maj relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT miaox relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT dingk relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT jiangb relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT hub relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT fuf relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT huangl relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT caom relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease AT zhangx relationshipofredcellindexwiththeseverityofchronicobstructivepulmonarydisease |
_version_ |
1724199529612312576 |