Predictive factors over time of health-related quality of life in COPD patients
Abstract Background Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated with HRQoL and whether they continue to have an influence in the medium...
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doaj-a8af221a81f44e198e8900f37c1789462020-11-25T03:29:46ZengBMCRespiratory Research1465-993X2020-06-0121111110.1186/s12931-020-01395-zPredictive factors over time of health-related quality of life in COPD patientsCristóbal Esteban0Inmaculada Arostegui1Amaia Aramburu2Javier Moraza3Josu Najera-Zuloaga4Myriam Aburto5Susana Aizpiri6Leyre Chasco7José M. Quintana8Respiratory Department, Hospital Galdakao-UsansoloDepartment of Applied Mathematics, Statistics and Operative Research, University of the Basque Country (UPV/EHU) and Basque Center for Applied Mathematics (BCAM)Respiratory Department, Hospital Galdakao-UsansoloRespiratory Department, Hospital Galdakao-UsansoloDepartment of Mechanics, Design and Industrial Organization, Universidad de DeustoRespiratory Department, Hospital Galdakao-UsansoloRespiratory Department, Hospital Galdakao-UsansoloRespiratory Department, Hospital Galdakao-UsansoloResearch Unit, Hospital Galdakao-UsansoloAbstract Background Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated with HRQoL and whether they continue to have an influence in the medium term, during follow-up. Methods Overall, 543 patients with COPD were included in this prospective observational longitudinal study. At all four visits during a 5-year follow-up, the patients completed the Saint George’s Respiratory Questionnaire (SGRQ), pulmonary function tests, the 6-min walk test (6MWT), and a physical activity (PA) questionnaire, among others measurements. Data on hospitalization for COPD exacerbations and comorbidities were retrieved from the personal electronic clinical record of each patient at every visit. Results The best fit to the data of the cohort was obtained with a beta-binomial distribution. The following variables were related over time to SGRQ components: age, inhaled medication, smoking habit, forced expiratory volume in one second, handgrip strength, 6MWT distance, body mass index, residual volume, diffusing capacity of the lung for carbon monoxide, PA (depending on level, 13 to 35% better HRQoL, in activity and impacts components), and hospitalizations (5 to 45% poorer HRQoL, depending on the component). Conclusions Among COPD patients, HRQoL was associated with the same variables throughout the study period (5-year follow-up), and the variables with the strongest influence were PA and hospitalizations.http://link.springer.com/article/10.1186/s12931-020-01395-zPulmonary disease, chronic obstructivePhysical activityHospitalizationsQuality of life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristóbal Esteban Inmaculada Arostegui Amaia Aramburu Javier Moraza Josu Najera-Zuloaga Myriam Aburto Susana Aizpiri Leyre Chasco José M. Quintana |
spellingShingle |
Cristóbal Esteban Inmaculada Arostegui Amaia Aramburu Javier Moraza Josu Najera-Zuloaga Myriam Aburto Susana Aizpiri Leyre Chasco José M. Quintana Predictive factors over time of health-related quality of life in COPD patients Respiratory Research Pulmonary disease, chronic obstructive Physical activity Hospitalizations Quality of life |
author_facet |
Cristóbal Esteban Inmaculada Arostegui Amaia Aramburu Javier Moraza Josu Najera-Zuloaga Myriam Aburto Susana Aizpiri Leyre Chasco José M. Quintana |
author_sort |
Cristóbal Esteban |
title |
Predictive factors over time of health-related quality of life in COPD patients |
title_short |
Predictive factors over time of health-related quality of life in COPD patients |
title_full |
Predictive factors over time of health-related quality of life in COPD patients |
title_fullStr |
Predictive factors over time of health-related quality of life in COPD patients |
title_full_unstemmed |
Predictive factors over time of health-related quality of life in COPD patients |
title_sort |
predictive factors over time of health-related quality of life in copd patients |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2020-06-01 |
description |
Abstract Background Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated with HRQoL and whether they continue to have an influence in the medium term, during follow-up. Methods Overall, 543 patients with COPD were included in this prospective observational longitudinal study. At all four visits during a 5-year follow-up, the patients completed the Saint George’s Respiratory Questionnaire (SGRQ), pulmonary function tests, the 6-min walk test (6MWT), and a physical activity (PA) questionnaire, among others measurements. Data on hospitalization for COPD exacerbations and comorbidities were retrieved from the personal electronic clinical record of each patient at every visit. Results The best fit to the data of the cohort was obtained with a beta-binomial distribution. The following variables were related over time to SGRQ components: age, inhaled medication, smoking habit, forced expiratory volume in one second, handgrip strength, 6MWT distance, body mass index, residual volume, diffusing capacity of the lung for carbon monoxide, PA (depending on level, 13 to 35% better HRQoL, in activity and impacts components), and hospitalizations (5 to 45% poorer HRQoL, depending on the component). Conclusions Among COPD patients, HRQoL was associated with the same variables throughout the study period (5-year follow-up), and the variables with the strongest influence were PA and hospitalizations. |
topic |
Pulmonary disease, chronic obstructive Physical activity Hospitalizations Quality of life |
url |
http://link.springer.com/article/10.1186/s12931-020-01395-z |
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