The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders

The relationship between endocrine hormones and the spectrum of rheumatic conditions has long been discussed in the literature, focusing primarily on sexual hormones, such as estrogens, androgens, prolactin (PRL). Estrogens are indeed involved in the pathogenesis of the main inflammatory arthritis t...

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Main Authors: Eugenia Bertoldo, Giovanni Adami, Maurizio Rossini, Alessandro Giollo, Giovanni Orsolini, Ombretta Viapiana, Davide Gatti, Angelo Fassio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.620920/full
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spelling doaj-a8b28dde615f433786bf6f9a09d45b5c2021-05-21T06:49:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-05-011210.3389/fendo.2021.620920620920The Emerging Roles of Endocrine Hormones in Different Arthritic DisordersEugenia BertoldoGiovanni AdamiMaurizio RossiniAlessandro GiolloGiovanni OrsoliniOmbretta ViapianaDavide GattiAngelo FassioThe relationship between endocrine hormones and the spectrum of rheumatic conditions has long been discussed in the literature, focusing primarily on sexual hormones, such as estrogens, androgens, prolactin (PRL). Estrogens are indeed involved in the pathogenesis of the main inflammatory arthritis thanks to their effects on the immune system, both stimulatory and inhibitory. The PRL system has been discovered in synovial tissue of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), patients and has been propose as a new potential therapeutic target. Besides sexual hormones, in the last years scientific interest about the crosstalk of immune system with other class of hormones has grown. Hormones acting on the bone tissue (i.e. parathyroid hormone, vitamin D) and modulators of the Wnt pathway (i.e. Dickkopf-1) have been demonstrated to play active role in inflammatory arthritis course, defining a new field of research named osteoimmunology. PTH, which is one of the main determinants of Dkkopf-1, plays a crucial role in bone erosions in RA and a correlation between PTH, Trabecular Bone Score (TBS) and disease activity has been found in ankylosing spondylitis (AS). In PSA is under studying the interaction among IL-17 and bone metabolism. The purpose of this review is to discuss and summarize the recent data about the interaction between endocrine hormone and immune system in the main rheumatic disorders, covering in particular the role of bone-related hormones and cytokines. We will describe this relationship from a biochemical, diagnostic and therapeutic perspective, with a particular focus on RA, PsA and AS.https://www.frontiersin.org/articles/10.3389/fendo.2021.620920/fullbone metabolismhormonesbone turnover markersrheumatic disordersparathyroid hormone
collection DOAJ
language English
format Article
sources DOAJ
author Eugenia Bertoldo
Giovanni Adami
Maurizio Rossini
Alessandro Giollo
Giovanni Orsolini
Ombretta Viapiana
Davide Gatti
Angelo Fassio
spellingShingle Eugenia Bertoldo
Giovanni Adami
Maurizio Rossini
Alessandro Giollo
Giovanni Orsolini
Ombretta Viapiana
Davide Gatti
Angelo Fassio
The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
Frontiers in Endocrinology
bone metabolism
hormones
bone turnover markers
rheumatic disorders
parathyroid hormone
author_facet Eugenia Bertoldo
Giovanni Adami
Maurizio Rossini
Alessandro Giollo
Giovanni Orsolini
Ombretta Viapiana
Davide Gatti
Angelo Fassio
author_sort Eugenia Bertoldo
title The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
title_short The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
title_full The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
title_fullStr The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
title_full_unstemmed The Emerging Roles of Endocrine Hormones in Different Arthritic Disorders
title_sort emerging roles of endocrine hormones in different arthritic disorders
publisher Frontiers Media S.A.
series Frontiers in Endocrinology
issn 1664-2392
publishDate 2021-05-01
description The relationship between endocrine hormones and the spectrum of rheumatic conditions has long been discussed in the literature, focusing primarily on sexual hormones, such as estrogens, androgens, prolactin (PRL). Estrogens are indeed involved in the pathogenesis of the main inflammatory arthritis thanks to their effects on the immune system, both stimulatory and inhibitory. The PRL system has been discovered in synovial tissue of rheumatoid arthritis (RA) and psoriatic arthritis (PsA), patients and has been propose as a new potential therapeutic target. Besides sexual hormones, in the last years scientific interest about the crosstalk of immune system with other class of hormones has grown. Hormones acting on the bone tissue (i.e. parathyroid hormone, vitamin D) and modulators of the Wnt pathway (i.e. Dickkopf-1) have been demonstrated to play active role in inflammatory arthritis course, defining a new field of research named osteoimmunology. PTH, which is one of the main determinants of Dkkopf-1, plays a crucial role in bone erosions in RA and a correlation between PTH, Trabecular Bone Score (TBS) and disease activity has been found in ankylosing spondylitis (AS). In PSA is under studying the interaction among IL-17 and bone metabolism. The purpose of this review is to discuss and summarize the recent data about the interaction between endocrine hormone and immune system in the main rheumatic disorders, covering in particular the role of bone-related hormones and cytokines. We will describe this relationship from a biochemical, diagnostic and therapeutic perspective, with a particular focus on RA, PsA and AS.
topic bone metabolism
hormones
bone turnover markers
rheumatic disorders
parathyroid hormone
url https://www.frontiersin.org/articles/10.3389/fendo.2021.620920/full
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