Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections
Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinic...
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doaj-a8b3933e5052489691f11d185f23f90c2021-02-10T08:36:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-02-011210.3389/fneur.2021.635753635753Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding InfectionsThomas Langerak0Irene van Rooij1Laura Doornekamp2Felicity Chandler3Mark Baptista4Harvey Yang5Marion P. G. Koopmans6Corine H. GeurtsvanKessel7Bart C. Jacobs8Bart C. Jacobs9Barry Rockx10Kirsten Adriani11Kirsten Adriani12Eric C. M. van Gorp13Department of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Neurology, St. Vincentius Hospital, Paramaribo, SurinameDepartment of Neurology, Academic Hospital Paramaribo, Paramaribo, SurinameDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Neurology, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Immunology, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Neurology, Zaans Medisch Centrum, Zaandam, NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, NetherlandsGuillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname.https://www.frontiersin.org/articles/10.3389/fneur.2021.635753/fullGuillain-Barré syndromeSurinameZika virusdengue virusarthropod borne viruses |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Langerak Irene van Rooij Laura Doornekamp Felicity Chandler Mark Baptista Harvey Yang Marion P. G. Koopmans Corine H. GeurtsvanKessel Bart C. Jacobs Bart C. Jacobs Barry Rockx Kirsten Adriani Kirsten Adriani Eric C. M. van Gorp |
spellingShingle |
Thomas Langerak Irene van Rooij Laura Doornekamp Felicity Chandler Mark Baptista Harvey Yang Marion P. G. Koopmans Corine H. GeurtsvanKessel Bart C. Jacobs Bart C. Jacobs Barry Rockx Kirsten Adriani Kirsten Adriani Eric C. M. van Gorp Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections Frontiers in Neurology Guillain-Barré syndrome Suriname Zika virus dengue virus arthropod borne viruses |
author_facet |
Thomas Langerak Irene van Rooij Laura Doornekamp Felicity Chandler Mark Baptista Harvey Yang Marion P. G. Koopmans Corine H. GeurtsvanKessel Bart C. Jacobs Bart C. Jacobs Barry Rockx Kirsten Adriani Kirsten Adriani Eric C. M. van Gorp |
author_sort |
Thomas Langerak |
title |
Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections |
title_short |
Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections |
title_full |
Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections |
title_fullStr |
Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections |
title_full_unstemmed |
Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections |
title_sort |
guillain-barré syndrome in suriname; clinical presentation and identification of preceding infections |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-02-01 |
description |
Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname. |
topic |
Guillain-Barré syndrome Suriname Zika virus dengue virus arthropod borne viruses |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.635753/full |
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