A Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research

A Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research

Prader-Willi syndrome (PWS) is a neurogenetic multifactorial disorder caused by the deletion or inactivation of paternally imprinted genes on human chromosome 15q11-q13. The affected homologous locus is on mouse chromosome 7C. The positional conservation and organization of genes including the impri...

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Bibliographic Details
Main Authors: Delf-Magnus Kummerfeld, Carsten A. Raabe, Juergen Brosius, Dingding Mo, Boris V. Skryabin, Timofey S. Rozhdestvensky
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
Prader-Willi syndrome (PWS)
Snord116
mouse models
Magel2
PWS imprinting center (IC)
non-coding RNAs
Online Access:https://www.mdpi.com/1422-0067/22/7/3613

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