First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice
The aim is to evaluate the efficacy of the first-line rituximab-containing therapy of B-cell lymphoproliferative diseases in Russian clinical practice between 2014 and 2017. Materials and methods. In the post-authorisation multicenter study EQUILIBRIUM were included 1 thousand patients aged from...
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IP Habib O.N.
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doaj-a8c86a1abee24252a6ffdffa30b488a62021-01-26T09:11:25ZrusIP Habib O.N.Современная онкология1815-14341815-14422020-07-0122211912510.26442/18151434.2020.2.20012531379First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practiceLali G. Babicheva0Irina V. Poddubnaya1Russian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationThe aim is to evaluate the efficacy of the first-line rituximab-containing therapy of B-cell lymphoproliferative diseases in Russian clinical practice between 2014 and 2017. Materials and methods. In the post-authorisation multicenter study EQUILIBRIUM were included 1 thousand patients aged from 21 to 91 with B-cell non-Hodgkins lymphoma or chronic lymphatic leukemia who had received at least 4 cycles of rituximab-containing therapy using the drug Acellbia. This article was devoted to the group of indolent non-Hodgkins lymphomas and included 253 patients: follicular lymphoma 51% of cases, marginal zone lymphoma 44% of patients, extremely rare were registered lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia in 3% and in 2% of cases, respectively. The median age in patients with indolent non-Hodgkins lymphomas was 62 years (2191 years). The vast majority of patients were diagnosed with stage IIIIV 190 (75%) of patients. More than 1/2 (53.4%) of patients in routine practice received R-CHOP therapy as a first-line. BR regimen was applied in 15.4% of cases, 14.2% of patients were treated with R-CVP/R-COP. We indicated rare use of rituximab as monotherapy in induction mode only 4.4% of patients. And 2.4% of patients were treated with fludarabine-containing therapy. Results. The final assessment of the effect was carried out after 68 cycles of treatment and as a result the overall effect was more than 90%: the frequency of complete remission was 61%, partial responses 32.9%. The progression admitted only in 17 (6.7%) patients among 253 observed. With a median of 15 months, the median of overall survival and event-free survival was not achieved. Conclusion. The use of the available and appropriate treatment according to the domestic clinical guidelines with the inclusion of the Russian biosimilar anti-CD20 monoclonal antibody Acellbia, demonstrates high direct efficacy and satisfactory long-term treatment results comparable to the retrospective analysis of the previous clinical studies of the original drug rituximab.https://modernonco.orscience.ru/1815-1434/article/viewFile/34967/23382non-hodgkin’s lymphomarituximabfollicular lymphomamarginal zone lymphomaroutine clinical practicethe first-line therapy |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Lali G. Babicheva Irina V. Poddubnaya |
spellingShingle |
Lali G. Babicheva Irina V. Poddubnaya First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice Современная онкология non-hodgkin’s lymphoma rituximab follicular lymphoma marginal zone lymphoma routine clinical practice the first-line therapy |
author_facet |
Lali G. Babicheva Irina V. Poddubnaya |
author_sort |
Lali G. Babicheva |
title |
First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice |
title_short |
First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice |
title_full |
First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice |
title_fullStr |
First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice |
title_full_unstemmed |
First-line therapy of indolent non-Hodgkin’s lymphoma in routine clinical practice |
title_sort |
first-line therapy of indolent non-hodgkin’s lymphoma in routine clinical practice |
publisher |
IP Habib O.N. |
series |
Современная онкология |
issn |
1815-1434 1815-1442 |
publishDate |
2020-07-01 |
description |
The aim is to evaluate the efficacy of the first-line rituximab-containing therapy of B-cell lymphoproliferative diseases in Russian clinical practice between 2014 and 2017.
Materials and methods. In the post-authorisation multicenter study EQUILIBRIUM were included 1 thousand patients aged from 21 to 91 with B-cell non-Hodgkins lymphoma or chronic lymphatic leukemia who had received at least 4 cycles of rituximab-containing therapy using the drug Acellbia. This article was devoted to the group of indolent non-Hodgkins lymphomas and included 253 patients: follicular lymphoma 51% of cases, marginal zone lymphoma 44% of patients, extremely rare were registered lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia in 3% and in 2% of cases, respectively. The median age in patients with indolent non-Hodgkins lymphomas was 62 years (2191 years). The vast majority of patients were diagnosed with stage IIIIV 190 (75%) of patients. More than 1/2 (53.4%) of patients in routine practice received R-CHOP therapy as a first-line. BR regimen was applied in 15.4% of cases, 14.2% of patients were treated with R-CVP/R-COP. We indicated rare use of rituximab as monotherapy in induction mode only 4.4% of patients. And 2.4% of patients were treated with fludarabine-containing therapy.
Results. The final assessment of the effect was carried out after 68 cycles of treatment and as a result the overall effect was more than 90%: the frequency of complete remission was 61%, partial responses 32.9%. The progression admitted only in 17 (6.7%) patients among 253 observed. With a median of 15 months, the median of overall survival and event-free survival was not achieved.
Conclusion. The use of the available and appropriate treatment according to the domestic clinical guidelines with the inclusion of the Russian biosimilar anti-CD20 monoclonal antibody Acellbia, demonstrates high direct efficacy and satisfactory long-term treatment results comparable to the retrospective analysis of the previous clinical studies of the original drug rituximab. |
topic |
non-hodgkin’s lymphoma rituximab follicular lymphoma marginal zone lymphoma routine clinical practice the first-line therapy |
url |
https://modernonco.orscience.ru/1815-1434/article/viewFile/34967/23382 |
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